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CAS 623174-20-9

:

Tasidotin hydrochloride

Description:
Tasidotin hydrochloride, with the CAS number 623174-20-9, is a synthetic compound that belongs to the class of peptide-based drugs. It is primarily recognized for its potential application in cancer therapy, particularly due to its mechanism of action as a microtubule destabilizer, which interferes with the normal function of the cytoskeleton in cancer cells, leading to cell cycle arrest and apoptosis. The substance is characterized by its hydrochloride salt form, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. Tasidotin exhibits a specific structure that includes a cyclic peptide backbone, contributing to its biological activity. In preclinical studies, it has shown promise against various tumor types, although its clinical development has faced challenges. Safety and efficacy profiles are still under investigation, and ongoing research aims to better understand its pharmacodynamics and pharmacokinetics. As with many investigational drugs, the full spectrum of its characteristics, including potential side effects and interactions, is still being elucidated through clinical trials.
Formula:C32H58N6O5HCl
InChI:InChI=1/C32H58N6O5.ClH/c1-19(2)24(33-28(40)25(20(3)4)35(10)11)30(42)36(12)26(21(5)6)31(43)38-18-14-16-23(38)29(41)37-17-13-15-22(37)27(39)34-32(7,8)9;/h19-26H,13-18H2,1-12H3,(H,33,40)(H,34,39);1H/t22-,23-,24-,25-,26-;/m0./s1
SMILES:CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=NC(C)(C)C)O)N=C([C@H](C(C)C)N(C)C)O.Cl
Synonyms:
  • Bsf 223651
  • Ilx 651
  • Lu 223651
  • Synthadotin
  • Tasidotin HCl
  • L-Prolinamide, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(1,1-dimethylethyl)-, monohydrochloride
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