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CAS 62357-86-2

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Desmopressin acetate trihydrate

Description:
Desmopressin acetate trihydrate is a synthetic analog of vasopressin, a naturally occurring hormone that regulates water retention in the body. It is primarily used in the treatment of conditions such as diabetes insipidus and bedwetting (nocturnal enuresis). The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration via oral or intranasal routes. Desmopressin acetate acts on the kidneys to promote water reabsorption, thereby concentrating urine and reducing urine output. Its pharmacological effects are attributed to its ability to bind to vasopressin receptors, particularly V2 receptors, enhancing aquaporin channel insertion in renal collecting ducts. The trihydrate form indicates that the compound contains three molecules of water, which can influence its stability and solubility. Desmopressin acetate is generally well-tolerated, but potential side effects may include headache, nausea, and changes in blood sodium levels. As with any medication, it is essential to use it under medical supervision to monitor for adverse effects and ensure appropriate dosing.
Formula:C48H74N14O17S2
InChI:InChI=1/C46H64N14O12S2.C2H4O2.3H2O/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4;;;/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4);3*1H2
SMILES:c1ccc(cc1)CC1C(=NC(CCC(=N)O)C(=NC(CC(=N)O)C(=NC(CSSCCC(=NC(Cc2ccc(cc2)O)C(=N1)O)O)C(=O)N1CCCC1C(=NC(CCCNC(=N)N)C(=NCC(=N)O)O)O)O)O)O.CC(=O)O.O.O.O
Synonyms:
  • 1-{[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}prolyl-N~5~-(diaminomethylidene)ornithylglycinamide acetate hydrate (1:1:3)
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