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CAS 6240-03-5

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1-Amino-3-hydroxyadamantane hydrochloride

Description:
1-Amino-3-hydroxyadamantane hydrochloride, also known as memantine hydrochloride, is a chemical compound characterized by its adamantane structure, which consists of a fused cycloalkane framework. This substance is a white to off-white crystalline powder that is soluble in water and exhibits a moderate pH level. It functions primarily as an N-methyl-D-aspartate (NMDA) receptor antagonist, making it significant in the treatment of neurodegenerative conditions, particularly Alzheimer's disease. The compound's mechanism involves modulating glutamate activity in the brain, which is crucial for memory and learning processes. Additionally, it has a relatively low potential for abuse and dependency compared to other psychoactive substances. The hydrochloride salt form enhances its stability and solubility, facilitating its use in pharmaceutical formulations. Safety and efficacy profiles have been established through clinical studies, although side effects may include dizziness, headache, and fatigue. Overall, 1-amino-3-hydroxyadamantane hydrochloride represents an important therapeutic agent in neurology.
Formula:C10H18ClNO
InChI:InChI=1S/C10H17NO.ClH/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9;/h7-8,12H,1-6,11H2;1H
SMILES:C1C2CC3(CC1CC(C2)(C3)O)N.Cl
Synonyms:
  • 3-Amino-1-adamantanol hydrochloride (1:1)
  • 3-Aminotricyclo[3.3.1.1(3,7)]decan-1-ol hydrochloride
  • Tricyclo[3.3.1.13,7]decan-1-ol, 3-amino-, hydrochloride (1:1)
  • 3-Amino-1-adamantanol hydrochloride
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