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CAS 62488-57-7

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Dihydro-5-azacytidine

Description:
Dihydro-5-azacytidine is a nucleoside analog that is structurally related to cytidine, featuring a nitrogen atom in place of a carbon atom in the pyrimidine ring. This modification imparts unique properties to the compound, making it of interest in various biochemical and pharmaceutical applications. It is characterized by its ability to inhibit DNA methyltransferases, which can influence gene expression and has potential implications in cancer therapy and epigenetic research. The compound is typically soluble in water and exhibits stability under physiological conditions, although it may be sensitive to extreme pH levels. Dihydro-5-azacytidine can be incorporated into RNA and DNA, affecting nucleic acid metabolism and function. Its mechanism of action and biological effects are subjects of ongoing research, particularly in the context of its potential therapeutic uses in treating diseases associated with abnormal DNA methylation patterns. As with many nucleoside analogs, careful consideration of its pharmacokinetics and toxicity is essential for its application in clinical settings.
Formula:C8H14N4O5
InChI:InChI=1S/C8H14N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h3-6,13-15H,1-2H2,(H3,9,10,11,16)/t3-,4-,5-,6-/m1/s1
InChI key:InChIKey=LJIRBXZDQGQUOO-KVTDHHQDSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)NC2
Synonyms:
  • 1,3,5-Triazin-2(1H)-one, 4-amino-3,6-dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
  • 4-Amino-1-(beta-D-ribofuranosyl)-1,2,5,6-tetrahydro-1,3,5-triazin-2-one
  • 4-Amino-3,6-dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,3,5-triazin-2(1H)-one
  • 6-amino-3-(beta-D-ribofuranosyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one
  • 6-amino-3-(beta-D-ribofuranosyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one hydrochloride (1:1)
  • 6-amino-3-pentofuranosyl-3,4-dihydro-1,3,5-triazin-2(1H)-one
  • Dhac
  • Dihydro-5-azacytidine
  • NSC 264-880
  • NSC 26480
  • See more synonyms
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