CAS 625095-61-6

9H-Purin-6-amine, 9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-, methanesulfonate (1:1)

Description:

9H-Purin-6-amine, 9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-, methanesulfonate (1:1), commonly referred to by its CAS number 625095-61-6, is a complex chemical compound that features a purine base structure, which is characteristic of nucleobases found in DNA and RNA. This compound includes a methanesulfonate group, which enhances its solubility and stability in aqueous environments. The presence of a phosphorinan moiety suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. The chlorophenyl substituent may contribute to the compound's biological activity, potentially influencing its interaction with cellular targets. Overall, this compound exemplifies the intricate design often found in drug development, where modifications to core structures can lead to enhanced efficacy and selectivity in therapeutic applications. Its specific properties, such as solubility, stability, and biological activity, would require empirical investigation to fully characterize its behavior in various environments.

Formula: C₁₇H₁₉ClN₅O₄P·CH₄O₃S

InChI: InChI=1S/C17H19ClN5O4P.CH4O3S/c18-13-3-1-2-12(8-13)14-4-6-26-28(24,27-14)11-25-7-5-23-10-22-15-16(19)20-9-21-17(15)23;1-5(2,3)4/h1-3,8-10,14H,4-7,11H2,(H2,19,20,21);1H3,(H,2,3,4)/t14-,28+;/m0./s1

InChI key: InChIKey=JXQUAHHUSMJUFV-HZPZRMRQSA-N

SMILES: C(COCP1(=O)O[C@@H](CCO1)C2=CC(Cl)=CC=C2)N3C=4C(N=C3)=C(N)N=CN4.S(C)(=O)(=O)O

Synonyms:

• 9-(2-{[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-yl]methoxy}ethyl)-9H-purin-6-amine methanesulfonate (1:1)
• 9H-Purin-6-amine, 9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-, methanesulfonate (1:1)
• 9H-Purin-6-amine, 9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-, monomethanesulfonate
• Hepavir B
• MB-06866，MB-6866，Hepavir B，Remofovir mesylate
• Mb 06866Q
• Pradefovir Mesilate
• Pradefovir mesylate
• Remofovir mesylate

Pradefovir mesylate

CAS: 625095-61-6

Pradefovir mesylate

Purity: ≥98%

Molecular weight: 519.9g/mol

Ref: 54-BUP00591

Pradefovir mesylate

CAS: 625095-61-6

Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.

Formula: C₁₈H₂₃ClN₅O₇PS

Purity: 98%

Color and Shape: Solid

Molecular weight: 519.9

Ref: TM-T19526

Pradefovir mesylate

CAS: 625095-61-6

Pradefovir mesylate is a prodrug that is converted to pradefovir in the human body. It has been shown to be an effective antiviral drug for the treatment of HIV infection and hepatitis B virus. Pradefovir prevents replication of the virus by blocking reverse transcriptase, which is required for viral DNA synthesis. In vitro studies have found that it also inhibits other members of the hepadnavirus family, such as hepatitis C and D, through its action on reverse transcriptase. This drug has a low toxicity profile in animal studies and can be given orally or intravenously. The drug's matrix effect may cause it to accumulate in regions of high fat content, such as the liver and spleen, although this property may also help it penetrate areas where viruses replicate, such as CD4+ cells.

Formula: C₁₈H₂₃ClN₅O₇PS

Purity: Min. 95%

Molecular weight: 519.9 g/mol

Ref: 3D-AAB09561