CAS 625115-55-1

Riociguat

Description:

Riociguat is a medication primarily used in the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). It functions as a soluble guanylate cyclase (sGC) stimulator, enhancing the nitric oxide signaling pathway, which leads to vasodilation and improved blood flow. The chemical formula of riociguat is C22H24N4O4S, and it features a complex structure that includes a pyrimidine ring and a thiophene moiety. Riociguat is characterized by its ability to increase intracellular cyclic guanosine monophosphate (cGMP) levels, promoting relaxation of vascular smooth muscle. The substance is typically administered orally and has a half-life that allows for once or twice daily dosing. Common side effects may include headache, dizziness, and gastrointestinal disturbances. Due to its mechanism of action, riociguat is contraindicated in patients taking nitrates or other sGC stimulators, as this can lead to significant hypotension. Overall, riociguat represents a novel therapeutic approach in managing specific forms of pulmonary hypertension.

Formula: C₂₀H₁₉FN₈O₂

InChI: InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)

InChI key: InChIKey=WXXSNCNJFUAIDG-UHFFFAOYSA-N

SMILES: C(N1N=C(C=2C1=NC=CC2)C=3N=C(N)C(N(C(OC)=O)C)=C(N)N3)C4=C(F)C=CC=C4

Synonyms:

• Adempas
• Bay 63-2521
• Bay 632521
• Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-, methyl ester
• Carbamic acid, [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]methyl-, methyl ester
• Methyl N-[4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-(methyl)carbamate
• Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamate
• N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
• Riociguat

RIOCIGUAT CRS

CAS: 625115-55-1

RIOCIGUAT CRS

Ref: 41-Y0002238

Riociguat

CAS: 625115-55-1

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₀H₁₉FN₈O₂

Color and Shape: White Powder

Molecular weight: 422.1615

Ref: 45-1604519

methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate

CAS: 625115-55-1

Formula: C₂₀H₁₉FN₈O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 422.4157

Ref: IN-DA00ECEL

Riociguat-13C-d3

CAS: 625115-55-1

Formula: C₁₉₁₃CH₁₆D₃FN₈O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 426.43

Ref: 4Z-R-080012

Riociguat

CAS: 625115-55-1

Formula: C₂₀H₁₉FN₈O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 422.42

Ref: 4Z-R-080001

Riociguat

CAS: 625115-55-1

Riociguat

Purity: ≥98%

Molecular weight: 422.42g/mol

Ref: 54-BUP15490

Riociguat

CAS: 625115-55-1

Formula: C₂₀H₁₉FN₈O₂

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 422.42

Ref: 3B-R0292

RIOCIGUAT

CAS: 625115-55-1

Purity: 95%

Molecular weight: 422.424011230469

Ref: 10-F856915

Riociguat

CAS: 625115-55-1

Color and Shape: Neat

Ref: 86-MM3923.00

Riociguat

CAS: 625115-55-1

Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial

Formula: C₂₀H₁₉FN₈O₂

Purity: 99.28% - 99.95%

Color and Shape: Solid

Molecular weight: 422.42

Ref: TM-T6968

Riociguat

Controlled Product

CAS: 625115-55-1

Applications Riociguat is used in the treatment for pulmonary hypertension.
References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);

Formula: C₂₀H₁₉FN₈O₂

Color and Shape: Neat

Molecular weight: 422.4157

Ref: TR-R520000

Riociguat-13C-d3

Controlled Product

CAS: 625115-55-1

Applications Riociguat-13C-d3 is the labelled analogue of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.
References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);

Formula: C₁₉₁₃CH₁₆D₃FN₈O₂

Color and Shape: Neat

Molecular weight: 426.43

Ref: TR-R520004