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CAS 62571-86-2

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Captopril

Description:
Captopril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. Its chemical formula is C9H15N3O3S, and it features a thiol group, which is crucial for its mechanism of action. Captopril is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The substance is typically administered orally and is known for its relatively rapid onset of action. Captopril is also associated with certain side effects, including cough, elevated potassium levels, and potential renal impairment. Its pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. The drug is metabolized in the liver and excreted primarily through the kidneys. Due to its unique structure and mechanism, Captopril has played a significant role in cardiovascular therapy since its introduction, paving the way for the development of other ACE inhibitors.
Formula:C9H15NO3S
InChI:InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChI key:InChIKey=FAKRSMQSSFJEIM-RQJHMYQMSA-N
SMILES:C([C@@H](CS)C)(=O)N1[C@H](C(O)=O)CCC1
Synonyms:
  • (-)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-<span class="text-smallcaps">L</span>-proline
  • (-)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
  • (2S)-1-(3-Mercapto-2-Methylpropionyl)-L-Proline
  • (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylate
  • (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
  • (S,S)-1-(D-3-Mercapto-2-Methyl-1-Oxopropyl)-L-Proline
  • 1-(2-Methyl-3-Sulfanylpropanoyl)Proline
  • <span class="text-smallcaps">L</span>-Captopril
  • <span class="text-smallcaps">L</span>-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (S)-
  • <span class="text-smallcaps">L</span>-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-
  • See more synonyms
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