CAS 626-61-9

4-Chloropyridine

Description:

4-Chloropyridine is an organic compound characterized by a pyridine ring substituted with a chlorine atom at the fourth position. Its molecular formula is C5H4ClN, and it has a molecular weight of approximately 131.54 g/mol. This colorless to pale yellow liquid exhibits a distinctive aromatic odor and is soluble in organic solvents such as ethanol and ether, but has limited solubility in water. 4-Chloropyridine is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is known for its reactivity, particularly in nucleophilic substitution reactions, due to the presence of the electronegative chlorine atom. Additionally, it can undergo various chemical transformations, including oxidation and reduction. Safety precautions are necessary when handling this compound, as it may be harmful if inhaled or ingested, and can cause skin and eye irritation. Proper storage in a cool, well-ventilated area away from incompatible substances is essential to ensure safety and stability.

Formula: C₅H₄ClN

InChI: InChI=1S/C5H4ClN/c6-5-1-3-7-4-2-5/h1-4H

InChI key: InChIKey=PVMNPAUTCMBOMO-UHFFFAOYSA-N

SMILES: ClC=1C=CN=CC1

Synonyms:

• Brn 0105875
• Pyridine, 4-chloro-
• γ-Chloropyridine
• 4-Chloropyridine
• 4-Chloropyridine
• 5-20-05-00410 (Beilstein Handbook Reference)

4-Chloropyridine

CAS: 626-61-9

Formula: C₅H₄ClN

Purity: 95%

Color and Shape: Solid

Molecular weight: 113.5450

Ref: IN-DA0039VU

Trazodone Impurity 20

CAS: 626-61-9

Formula: C₅H₄ClN

Molecular weight: 113.54

Ref: 4Z-T-3339

4-Chloropyridine

CAS: 626-61-9

Purity: 95%

Molecular weight: 113.5400009

Ref: 10-F619181

4-Chloropyridine

CAS: 626-61-9

4-Chloropyridine acts as an inhibitor of Nicotinamide N-methyltransferase (NNMT). Serving as a substrate for NNMT, this compound enhances the electrophilicity at the C4 position through methylation of the pyridine nitrogen. This modification facilitates an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to suicidal activity inhibition of the enzyme. 4-Chloropyridine is a promising candidate for the development of activity-based probes targeting NNMT functions.

Formula: C₅H₄ClN

Color and Shape: Solid

Molecular weight: 113.55

Ref: TM-T201645