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CAS 62621-13-0

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(D-Ser4)-Leuprolide

Description:
(D-Ser4)-Leuprolide is a synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH). It is characterized by its ability to inhibit the release of gonadotropins, which are hormones that stimulate the gonads. This compound is primarily used in the treatment of hormone-sensitive conditions, such as prostate cancer and endometriosis, by suppressing the production of sex hormones. The structure of (D-Ser4)-Leuprolide includes a modified amino acid sequence that enhances its stability and potency compared to the native GnRH. It is typically administered via subcutaneous injection and has a prolonged half-life due to its resistance to enzymatic degradation. The compound is classified as a nonapeptide, and its pharmacological effects are mediated through binding to GnRH receptors, leading to a downregulation of the hypothalamic-pituitary-gonadal axis. Overall, (D-Ser4)-Leuprolide exemplifies the use of peptide analogs in therapeutic applications, showcasing the importance of structural modifications in enhancing drug efficacy.
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