CAS 62658-63-3

Bopindolol

Description:

Bopindolol is a non-selective beta-adrenergic antagonist, primarily used in the treatment of hypertension and certain types of heart conditions. It functions by blocking the action of epinephrine and norepinephrine on beta-adrenergic receptors, leading to a decrease in heart rate and blood pressure. The chemical structure of Bopindolol includes a phenolic group and a piperidine moiety, contributing to its pharmacological properties. It is typically administered orally and has a moderate bioavailability. Bopindolol is characterized by its lipophilicity, which influences its distribution in the body and its ability to cross biological membranes. The substance is also known for its relatively long half-life, allowing for once-daily dosing in clinical settings. As with other beta-blockers, potential side effects may include fatigue, dizziness, and respiratory issues, particularly in patients with pre-existing conditions. Overall, Bopindolol represents a valuable option in cardiovascular therapy, with its efficacy and safety profile being well-documented in clinical studies.

Formula: C₂₃H₂₈N₂O₃

InChI: InChI=1S/C23H28N2O3/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17/h5-13,18,24-25H,14-15H2,1-4H3

InChI key: InChIKey=UUOJIACWOAYWEZ-UHFFFAOYSA-N

SMILES: O(CC(OC(=O)C1=CC=CC=C1)CNC(C)(C)C)C2=C3C(NC(C)=C3)=CC=C2

Synonyms:

• (±)-1-(tert-Butylamino)-3-[(2-methylindol-4-yl)oxy]-2-propanol Benzoate (Ester)
• (±)1-[(1,1-Dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol Benzoate Ester
• 1-(tert-Butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate
• 2-(tert-butylamino)-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate
• 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, 2-benzoate
• 2-[(1,1-dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate
• 2-propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester)
• 82857-38-3
• Sandonorm
• Wandonorm
• Bopindolol

rac Bopindolol

CAS: 62658-63-3

Formula: C₂₃H₂₈N₂O₃

Color and Shape: Solid

Molecular weight: 380.4800

Ref: IN-DA00EFBI

Bopindolol

CAS: 62658-63-3

Formula: C₂₃H₂₈N₂O₃

Molecular weight: 380.48

Ref: 7W-GP4368

rac Bopindolol

Controlled Product

CAS: 62658-63-3

Applications Bopindolol is an ester prodrug of Pindolol (P468000). Bopindolol is a long acting β-adrenoceptor blocking agent. Bopindolol displays antispasmogenic activity mediated by α1-adrenoceptors and 5-HT2 receptors.
References Turner, D.R. et al.: Br. J. Clin. Pharmacol., 17, 295 (1984); Brodde, O.E. et al.: J. Cardio. Pharmacol., 8, S70 91986); Doggrell, S.A.: Med, Sci. Res., 17, 681 (1989);

Formula: C₂₃H₂₈N₂O₃

Color and Shape: Neat

Molecular weight: 380.48

Ref: TR-B675400

Bopindolol

CAS: 62658-63-3

Bopindolol is a beta-adrenergic receptor antagonist that has been shown to be effective in the treatment of cardiac and bowel diseases. This drug binds to the beta-adrenergic receptor, which is found on the surface of cells, and blocks the binding of epinephrine or norepinephrine. It has also been shown to have a role in the regulation of immune system function by inhibiting toll-like receptor signaling pathways. Bopindolol has also been shown to inhibit picolinic acid production from tryptophan in human serum, which may be due to its ability to bind protein genes. In addition, it was found that bopindolol inhibits the action of methylamine (MA) on receptors for acetylcholine at the neuromuscular junction, as well as other receptors such as alpha-adrenergic and histamine H1 receptors. Bopindolol can also be used as an electrochemical detector for

Formula: C₂₃H₂₈N₂O₃

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 380.48 g/mol

Ref: 3D-FB37307

Bopindolol

CAS: 62658-63-3

Bopindolol: oral β1/β2-ARs antagonist and partial agonist; prodrug of pindolol for hypertension research.

Formula: C₂₃H₂₈N₂O₃

Color and Shape: Solid

Molecular weight: 380.48

Ref: TM-T9451