CAS 62928-11-4

(OC-6-33)-Dichlorodihydroxybis(2-propanamine)platinum

Description:

(OC-6-33)-Dichlorodihydroxybis(2-propanamine)platinum, with the CAS number 62928-11-4, is a platinum-based coordination compound that exhibits unique characteristics due to its metal-ligand interactions. This compound features a platinum center coordinated to two chloride ions, two hydroxy groups, and two 2-propanamine ligands, which contribute to its overall stability and reactivity. The presence of the hydroxy groups enhances its solubility in polar solvents and may influence its biological activity, making it of interest in medicinal chemistry, particularly in cancer research. The compound's structure allows for potential interactions with biological macromolecules, which can lead to cytotoxic effects against certain cancer cell lines. Additionally, the steric and electronic properties imparted by the 2-propanamine ligands can affect the compound's pharmacokinetics and bioavailability. Overall, this platinum complex represents a class of compounds that are being explored for their therapeutic potential, particularly in the context of targeted cancer therapies.

Formula: C₆H₂₀Cl₂N₂O₂Pt

InChI: InChI=1S/2C3H9N.2ClH.2H2O.Pt/c2*1-3(2)4;;;;;/h2*3H,4H2,1-2H3;2*1H;2*1H2;/q;;;;;;+4/p-4

InChI key: InChIKey=FXSKHQLAUMGYJK-UHFFFAOYSA-J

SMILES: [NH2]([Pt+4]([NH2]C(C)C)([Cl-])([Cl-])([OH-])[OH-])C(C)C

Synonyms:

• (OC-6-33)-Dichlorodihydroxybis(2-propanamine)platinum
• 2-Propanamine, platinum complex
• Chip
• Dichlorodihydroxybis(2-propanamine)-(OC-6-33)platinum
• Dichloroplatinum(2+) Propan-2-Ylazanide Hydrate (1:2:2)
• Jm-9
• Nsc-256927
• Platinum, dichlorodihydroxybis(2-propanamine)-, (OC-6-33)-
• Propan-2-Amine - Dichloroplatinum Hydrate (2:1:2)
• cis,trans,cis-Dichlorodihydroxobis(isopropylamine)platinum
• cis-Dichloro-trans-dihydroxybis(isopropylamine)platinum(IV)

Iproplatin

CAS: 62928-11-4

Applications Iproplatin is a platinum anticancer agent that inhibits protein kinase C in rats.
References Sharma, P., et al.: Biochem. Soc. Trans., 25, 73S (1997); LeBlanc, G. A., et al.: Cancer Res., 52, 540 (1992)

Formula: C₃H₉NCl·PtOH

Color and Shape: Neat

Molecular weight: 418.221

Ref: TR-I740520

Iproplatin

CAS: 62928-11-4

Iproplatin, a synthetic platinum compound similar to cisplatin, forms DNA crosslinks causing cell death but shows in vitro tumor resistance.

Formula: C₆H₂₀Cl₂N₂O₂Pt

Color and Shape: Solid

Molecular weight: 418.22

Ref: TM-T32189