CAS 62996-74-1

Staurosporine

Description:

Staurosporine is a potent alkaloid derived from the bacterium Streptomyces staurosporeus, known for its broad-spectrum inhibitory effects on protein kinases. It is characterized by its complex tetracyclic structure, which contributes to its biological activity. Staurosporine exhibits a high affinity for various kinases, including those involved in cell signaling pathways, making it a valuable tool in research for studying cellular processes such as apoptosis and cell proliferation. The compound is typically used in laboratory settings to investigate the mechanisms of cancer and other diseases. Staurosporine is also recognized for its potential therapeutic applications, although its use is limited due to its non-selective nature and associated toxicity. In terms of physical properties, it is a crystalline solid that is soluble in organic solvents but has limited solubility in water. As a research chemical, it is important to handle staurosporine with care, adhering to safety protocols due to its potent biological effects.

Formula: C₂₈H₂₆N₄O₃

InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/p+1/t17-,20-,26-,28+/m1/s1

InChI key: InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8

Synonyms:

• (5R,6S,7S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5R,6S,7S,9S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-N,5-dimethyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-aminium
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
• 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• Alkaloid AM-2282 from Streptomyces
• Am-2282
• Antibiotic 230
• Antibiotic AM 2282
• Ccris 3272
• Cgp 39360
• Staurosporin
• (+)-Staurosporine
• Staurosporine
• STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
• [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• Staurosporine,AM-2282,STS
• STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+%
• Stauroporine
• [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE
• 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE
• STAUROSPORINE, STREPTOMYCES STAUROSPOREUS
• STAUROSPORINE, STREPTOMYCES SPECIES
• Staurosporine, Antibiotic AM-2282
• (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt
• STAUROSPORINE, 99+%.
• ANTIBIOTIC M 193
• 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• STSP
• Staurosporineinsolution
• InSolution Staurosporine, Streptomyces sp
• Staurosporine,98%
• [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• STAUROSPORINE READY-MADE SOLUTION
• STAUROSPORINE FROM STREPTOMYCES SP.
• Staurosporine(CGP 41251)
• [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 466.54

Ref: 3B-T4000

Staurosporine, 99+%

CAS: 62996-74-1

Staurosporine, 62996-74-1, is a cell-permeable bacterial alkyloid and protein kinase inhibitor with anti-cancer properties. Learn more at Thermo Fisher Scientific.

Formula: C₂₈H₂₆N₄O₃

Purity: 99+%

Color and Shape: Crystalline powder or granular, White to pale cream to yellow

Molecular weight: 466.54

Ref: 02-J62837

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purity: 100.0%

Color and Shape: Yellow powder

Molecular weight: 466.0

Ref: 8R-PB0005

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 466.5310

Ref: IN-DA00365L

Staurosporine

CAS: 62996-74-1

Staurosporine

Purity: ≥98%

Molecular weight: 466.53g/mol

Ref: 54-BUP12221

Staurosporine, from Streptomyces sp.

CAS: 62996-74-1

Staurosporine, from Streptomyces sp.

Formula: C₂₈H₂₆N₄O₃

Purity: 98%

Color and Shape: off-white powder

Molecular weight: 466.53103g/mol

Ref: 54-BIS0504

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Molecular weight: 466.54

Ref: 4Z-S-172001

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Color and Shape: Neat

Molecular weight: 466.53

Ref: 04-C16974200

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Purity: (HPLC) ≥ 98.0%

Color and Shape: Off-white to yellow solid

Molecular weight: 466.54

Ref: 7W-GA8507

Staurosporine

CAS: 62996-74-1

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr

Formula: C₂₈H₂₆N₄O₃

Purity: 99.24% - 99.82%

Color and Shape: Off-White Powder

Molecular weight: 466.53

Ref: TM-T6680

Staurosporine

Controlled Product

CAS: 62996-74-1

Inhibitor of protein kinases; induces apoptosis; anti-cancer

Formula: C₂₈H₂₆N₄O₃

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 466.53 g/mol

Ref: 3D-AS27871

Staurosporine

CAS: 62996-74-1

Purity: 98%

Molecular weight: 466.2

Ref: 10-F795841

Staurosporin

Controlled Product

CAS: 62996-74-1

Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),

Formula: C₂₈H₂₆N₄O₃

Color and Shape: Neat

Molecular weight: 466.53

Ref: TR-S685000

Staurosporine

CAS: 62996-74-1

Staurosporine is a fluorogenic substrate for the enzyme staurosporinase that is used in food testing, environmental testing, and diagnostics. It can be conjugated to an antibody or other protein to produce a ligand that binds to a receptor on the cell surface. Staurosporine has been shown to inhibit the activity of various enzymes including phospholipase A2, phospholipase C, and protein kinase C. It also inhibits bacterial DNA gyrase and topoisomerase IV. The fluorescence of staurosporine can be detected with luminometers or fluorescent microscopes.

Formula: C₂₈H₂₆N₄O₃

Purity: Min. 95%

Molecular weight: 466.53 g/mol

Ref: 3D-AS182928

Staurosporine

CAS: 62996-74-1

Formula: C₂₈H₂₆N₄O₃

Molecular weight: 466.5

Ref: ST-EA-CP-M107008