CAS 62997-67-5

8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)amphotericin B

Description:

8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)amphotericin B is a derivative of amphotericin B, a polyene antifungal antibiotic derived from Streptomyces nodosus. This compound exhibits a complex structure characterized by multiple hydroxyl groups and a glycosylated moiety, which contribute to its biological activity and solubility properties. The presence of the dideoxy sugar enhances its interaction with fungal cell membranes, potentially improving its antifungal efficacy while reducing toxicity to human cells. The modifications in the molecular structure, such as the dideoxy and dihydroxy groups, may influence its pharmacokinetics and pharmacodynamics, making it a subject of interest in medicinal chemistry for developing more effective antifungal agents. Its CAS number, 62997-67-5, allows for precise identification in chemical databases and literature. Overall, this compound represents a significant modification of the parent amphotericin B structure, aimed at optimizing its therapeutic profile against fungal infections.

Formula: C₅₃H₈₅NO₂₀

InChI: InChI=1S/C53H85NO20/c1-29-18-16-14-12-10-8-6-7-9-11-13-15-17-19-37(72-52-49(65)46(54)48(64)33(5)71-52)25-42-45(51(66)67)41(61)28-53(68,74-42)27-40(60)38(58)21-20-34(55)22-35(56)23-36(57)24-43(62)69-31(3)30(2)50(29)73-44-26-39(59)47(63)32(4)70-44/h6-7,9,11-19,29-42,44-50,52,55-61,63-65,68H,8,10,20-28,54H2,1-5H3,(H,66,67)

InChI key: InChIKey=IKYMLQOHQLVORI-UHFFFAOYSA-N

SMILES: C(O)(=O)C1C2OC(O)(CC1O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)OC(C)C(C)C(OC3CC(O)C(O)C(C)O3)C(C)C=CC=CCCC=CC=CC=CC=CC(OC4C(O)C(N)C(O)C(C)O4)C2

Synonyms:

• Nystatin A1, 35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)-
• Amphotericin B, 8,9-dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-17-[(2,6-dideoxy-L-ribo-hexopyranosyl)oxy]-1,3,4,7,9,11,37-heptahydroxy-15,16,18-trimethyl-13-oxo-
• 14,39-Dioxabicyclo[33.3.1]nonatriacontane, nystatin A1 deriv.
• 8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)amphotericin B

8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)amphotericin B

CAS: 62997-67-5

Formula: C₅₃H₈₅NO₂₀

Molecular weight: 1056.2367

Ref: IN-DA01EFAL

Nystatin A3

CAS: 62997-67-5

Formula: C₅₃H₈₅NO₂₀

Molecular weight: 1056.25

Ref: 4Z-N-082003

Nystatin A3

CAS: 62997-67-5

Nystatin A3 (Fungicidin) , which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal

Formula: C₅₃H₈₅NO₂₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 1056.24

Ref: TM-T6913

Nystatin A3

CAS: 62997-67-5

Formula: C₅₃H₈₅NO₂₀

Molecular weight: 1056.25

Ref: ST-EA-CP-N87003

Nystatin A3

CAS: 62997-67-5

8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35-O-(2,6-dideoxy-L-ribo-hexopyranosyl)amphotericin B is an antifungal drug that belongs to the class of polyene macrolides. It is a potent inhibitor of Candida albicans and Candida glabrata. This compound has been shown to have synergistic effects when used in combination with nystatin against C. albicans. 8,9-Dideoxy-28,29-dihydro-7,10-dihydroxy-35O-(2,6 - dideoxy - L - ribo - hexopyranosyl)amphotericin B also inhibits toll like receptor 4 (TLR4), which is responsible for the induction of inflammatory cytokines such as IL1B and IL8

Formula: C₅₃H₈₅NO₂₀

Purity: Min. 95%

Molecular weight: 1,056.24 g/mol

Ref: 3D-MD146814