CAS 63-45-6

Primaquine diphosphate

Description:

Primaquine diphosphate is an antimalarial medication primarily used to treat and prevent malaria, particularly the relapsing forms caused by Plasmodium vivax and Plasmodium ovale. It is a synthetic derivative of quinoline and is characterized by its ability to act on the liver stages of the malaria parasite, thereby preventing relapse. The compound is typically administered in its diphosphate salt form, which enhances its solubility and bioavailability. Primaquine works by generating reactive oxygen species that damage the parasite's cellular components. It is important to note that primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening before treatment. The drug is generally well-absorbed when taken orally and has a relatively short half-life, requiring a specific dosing regimen to ensure efficacy. Additionally, primaquine is contraindicated during pregnancy and in certain populations due to potential adverse effects. Overall, primaquine diphosphate plays a crucial role in malaria eradication efforts, particularly in preventing the recurrence of the disease.

Formula: C₁₅H₂₁N₃O·2H₃O₄P

InChI: InChI=1S/C15H21N3O.H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;(H3,1,2,3,4)

InChI key: InChIKey=RKFFPTPBADAVDU-UHFFFAOYSA-N

SMILES: P(=O)(O)(O)O.N(C(CCCN)C)C=1C2=C(C=C(OC)C1)C=CC=N2

Synonyms:

• 1,4-Pentanediamine, N⁴-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
• 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline di(dihydrogen phosphate)
• 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate
• Camden
• Malquine
• NSC 149765
• N~4~-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2)
• Pharmaniaga
• Primaquine Phosphate
• Primaquine bisphosphate
• Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-, diphosphate
• Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-, phosphate (1:2)
• Wr 2975

PRIMAQUINE DIPHOSPHATE CRS

CAS: 63-45-6

PRIMAQUINE DIPHOSPHATE CRS

Formula: C₁₅H₂₇N₃O₉P₂

Color and Shape: Crystalline Powder. Orange. Powder.

Molecular weight: 455.3371

Ref: 41-P2940000

Primaquine Phosphate

CAS: 63-45-6

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: C₁₅H₂₁N₃OH₃PO₄

Color and Shape: Orange Red Crystalline Powder

Molecular weight: 455.34

Ref: 45-1561507

Primaquine diphosphate

CAS: 63-45-6

Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties.

Formula: C₁₅H₂₁N₃O·2H₃PO₄

Purity: 99.73% - 99.82%

Color and Shape: Orange Powder

Molecular weight: 455.34

Ref: TM-T0850

Primaquine diphosphate

CAS: 63-45-6

Primaquine diphosphate

Purity: ≥98%

Molecular weight: 455.34g/mol

Ref: 54-BUP18871

Primaquine diphosphate

CAS: 63-45-6

Primaquine diphosphate

Purity: 98%

Molecular weight: 455.34g/mol

Ref: 54-OR1023553

Primaquine Diphosphate

CAS: 63-45-6

Formula: C₁₅H₂₁N₃O·2H₃O₄P

Molecular weight: 259.35 2 97.99

Ref: 4Z-P-296001

Primaquine-13C-d3 Diphosphate

CAS: 63-45-6

Formula: C₁₄₁₃CH₂₂D₃N₃O₆P·2H₃O₄P

Molecular weight: 378.36 2*97.99

Ref: 4Z-P-296005

Primaquine Diphosphate

Controlled Product

CAS: 63-45-6

Applications Antimalarial.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Marrs, T., et al.: Toxicol Lett., 36, 281 (1987), Karbwang, J., et al.: Clin. Pharmacokinetic., 27, 104 (1994), Noedl, H., et al.: Antimicrob. Agents Chemother., 45, 2106 (2010)

Formula: C₁₅H₂₁N₃O·2H₃O₄P

Purity: >90%

Color and Shape: Neat

Molecular weight: 455.34

Ref: TR-P733500

Primaquine diphosphate

Controlled Product

CAS: 63-45-6

Primaquine is an antimalarial drug that belongs to the class of natural compounds. It works by inhibiting the activity of blood cells and preventing malaria parasites from reproducing in the red blood cells. Primaquine diphosphate (PQDP) is a recombinant cytochrome P450 enzyme that has been shown to have high activity against Mycobacterium tuberculosis and other bacteria. PQDP is a strong inhibitor of cytochrome P450 enzymes, which are involved in drug metabolism, leading to serious drug interactions with many drugs such as warfarin, phenytoin, or oral contraceptives. This recombinant enzyme also has been shown to bind to toll-like receptor 2 (TLR2) on macrophages and monocytes, which can lead to inflammation in the bowel.

Formula: C₁₅H₂₇N₃O₉P₂

Color and Shape: Powder

Molecular weight: 455.34 g/mol

Ref: 3D-FP27162