CAS 63-45-6
:Primaquine diphosphate
Description:
Primaquine diphosphate is an antimalarial medication primarily used to treat and prevent malaria, particularly the relapsing forms caused by Plasmodium vivax and Plasmodium ovale. It is a synthetic derivative of quinoline and is characterized by its ability to act on the liver stages of the malaria parasite, thereby preventing relapse. The compound is typically administered in its diphosphate salt form, which enhances its solubility and bioavailability. Primaquine works by generating reactive oxygen species that damage the parasite's cellular components. It is important to note that primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening before treatment. The drug is generally well-absorbed when taken orally and has a relatively short half-life, requiring a specific dosing regimen to ensure efficacy. Additionally, primaquine is contraindicated during pregnancy and in certain populations due to potential adverse effects. Overall, primaquine diphosphate plays a crucial role in malaria eradication efforts, particularly in preventing the recurrence of the disease.
Formula:C15H21N3O·2H3O4P
InChI:InChI=1S/C15H21N3O.H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;(H3,1,2,3,4)
InChI key:InChIKey=RKFFPTPBADAVDU-UHFFFAOYSA-N
SMILES:P(=O)(O)(O)O.N(C(CCCN)C)C=1C2=C(C=C(OC)C1)C=CC=N2
Synonyms:- 1,4-Pentanediamine, N<sup>4</sup>-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
- 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline di(dihydrogen phosphate)
- 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate
- Camden
- Malquine
- NSC 149765
- N~4~-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2)
- Pharmaniaga
- Primaquine Phosphate
- Primaquine bisphosphate
- Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-, diphosphate
- Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-, phosphate (1:2)
- Wr 2975
- See more synonyms
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Found 9 products.
PRIMAQUINE DIPHOSPHATE CRS
CAS:PRIMAQUINE DIPHOSPHATE CRSFormula:C15H27N3O9P2Color and Shape:Crystalline Powder. Orange. Powder.Molecular weight:455.3371Primaquine Phosphate
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFormula:C15H21N3OH3PO4Color and Shape:Orange Red Crystalline PowderMolecular weight:455.34Primaquine diphosphate
CAS:<p>Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties.</p>Formula:C15H21N3O·2H3PO4Purity:98.06% - 99.73%Color and Shape:Orange PowderMolecular weight:455.34Primaquine Diphosphate
CAS:Controlled Product<p>Applications Antimalarial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marrs, T., et al.: Toxicol Lett., 36, 281 (1987), Karbwang, J., et al.: Clin. Pharmacokinetic., 27, 104 (1994), Noedl, H., et al.: Antimicrob. Agents Chemother., 45, 2106 (2010)<br></p>Formula:C15H21N3O·2H3O4PPurity:>90%Color and Shape:NeatMolecular weight:455.34Primaquine diphosphate
CAS:Controlled Product<p>Primaquine is an antimalarial drug that belongs to the class of natural compounds. It works by inhibiting the activity of blood cells and preventing malaria parasites from reproducing in the red blood cells. Primaquine diphosphate (PQDP) is a recombinant cytochrome P450 enzyme that has been shown to have high activity against Mycobacterium tuberculosis and other bacteria. PQDP is a strong inhibitor of cytochrome P450 enzymes, which are involved in drug metabolism, leading to serious drug interactions with many drugs such as warfarin, phenytoin, or oral contraceptives. This recombinant enzyme also has been shown to bind to toll-like receptor 2 (TLR2) on macrophages and monocytes, which can lead to inflammation in the bowel.</p>Formula:C15H27N3O9P2Color and Shape:PowderMolecular weight:455.34 g/mol
