CAS 630-22-8

2,2-Dimethylpropanethioamide

Description:

2,2-Dimethylpropanethioamide, with the CAS number 630-22-8, is an organic compound characterized by its thioamide functional group, which features a sulfur atom bonded to a carbonyl carbon. This compound has a molecular structure that includes two methyl groups attached to the carbon adjacent to the thioamide group, contributing to its branched nature. It is typically a colorless to pale yellow liquid with a distinctive odor. The presence of the thioamide group imparts unique chemical properties, such as the ability to participate in various nucleophilic reactions and the potential for hydrogen bonding due to the nitrogen atom. 2,2-Dimethylpropanethioamide is soluble in organic solvents and has limited solubility in water, reflecting its hydrophobic characteristics. It is used in organic synthesis and may serve as an intermediate in the production of pharmaceuticals or agrochemicals. Safety data should be consulted for handling and storage, as thioamides can exhibit toxicity and require appropriate precautions.

Formula: C₅H₁₁NS

InChI: InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)

InChI key: InChIKey=FJZJUSOFGBXHCV-UHFFFAOYSA-N

SMILES: C(C(N)=S)(C)(C)C

Synonyms:

• 2,2-Dimethylpropanethioamide
• 2,2-Dimethylthiopropionamide
• NSC 381432
• Neopentanethioamide
• Propanethioamide, 2,2-Dimethyl-
• Propionamide, 2,2-dimethylthio-
• Thiopivalamide

2,2,2-Trimethylthioacetamide, 97%

CAS: 630-22-8

2,2,2-Trimethylthioacetamide, is used as a pharmaceutical and organic intermediate, an important amino protective agent, pharmaceutical and synthetic organic make intermediates, organic synthesis used to introduce t- Boc protect gene species. This Thermo Scientific Chemicals brand product was origin

Formula: C₅H₁₁NS

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder, White

Molecular weight: 117.21

Ref: 02-H32092

2,2-Dimethylpropanethioamide

CAS: 630-22-8

Formula: C₅H₁₁NS

Purity: 98%

Color and Shape: Solid

Molecular weight: 117.2125

Ref: IN-DA0036X7

2,2-Dimethylpropanethioamide

CAS: 630-22-8

2,2-Dimethylpropanethioamide

Formula: C₅H₁₁NS

Purity: 98%

Color and Shape: white solid

Molecular weight: 117.21g/mol

Ref: 54-OR936945

Dabrafenib Impurity 24

CAS: 630-22-8

Formula: C₅H₁₁NS

Molecular weight: 117.21

Ref: 4Z-D-108027

2,2-Dimethylthiopropionamide

CAS: 630-22-8

Applications 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
References Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);

Formula: C₅H₁₁NS

Color and Shape: White

Molecular weight: 117.21

Ref: TR-T796135

2,2-Dimethylthiopropionamide

CAS: 630-22-8

2,2-Dimethylthiopropionamide is an organic compound with the chemical formula C4H7NOS. It is a nucleophilic, unsymmetrical, n-benzyltrifluoroacetamide that is soluble in chloroform and reacts with nucleophiles to give products of desulfurization. 2,2-Dimethylthiopropionamide has been shown to react with electron-deficient amines such as azetidine and elucidate their structures. The reaction of 2,2-Dimethylthiopropionamide with chloroformate gives a dipole product and can be analysed by infrared spectroscopy.

Formula: C₅H₁₁NS

Purity: Min. 95%

Molecular weight: 117.21 g/mol

Ref: 3D-FD36176

2,2-Dimethylpropanethioamide

CAS: 630-22-8

Formula: C₅H₁₁NS

Purity: 98%

Color and Shape: Crystalline

Molecular weight: 117.21

Ref: 10-F044516

2,2-Dimethylthiopropionamide

CAS: 630-22-8

Formula: C₅H₁₁NS

Molecular weight: 117.21

Ref: ST-EA-CP-D127038