CAS 630125-99-4

4-Pyrimidinamine, 6-(4-aminophenoxy)-N-methyl-

Description:

4-Pyrimidinamine, 6-(4-aminophenoxy)-N-methyl- is a chemical compound characterized by its pyrimidine and phenoxy functional groups. It features a pyrimidine ring substituted at the 6-position with a 4-aminophenoxy group and an N-methyl group attached to the amino group. This structure suggests potential biological activity, particularly in medicinal chemistry, where such compounds may exhibit properties as enzyme inhibitors or receptor modulators. The presence of both amino and phenoxy groups can enhance solubility and bioavailability, making it a candidate for pharmaceutical applications. The compound's molecular weight, solubility, and stability are influenced by its functional groups, which can also affect its reactivity and interaction with biological targets. Additionally, the compound's CAS number, 630125-99-4, allows for easy identification and retrieval of information in chemical databases. Overall, 4-Pyrimidinamine, 6-(4-aminophenoxy)-N-methyl- represents a class of compounds that may be of interest in drug discovery and development.

Formula: C₁₁H₁₂N₄O

6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine

Controlled Product

CAS: 630125-99-4

Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Formula: C₁₁H₁₂N₄O

Color and Shape: Neat

Molecular weight: 216.239

Ref: TR-A125990