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CAS 63142-70-1

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Ribavirin diphosphate

Description:
Ribavirin diphosphate is the active metabolite of the antiviral drug ribavirin, which is primarily used in the treatment of viral infections, particularly hepatitis C and certain viral hemorrhagic fevers. As a nucleotide analogue, ribavirin diphosphate exhibits characteristics that enable it to interfere with viral RNA synthesis. It is a phosphorylated form of ribavirin, possessing two phosphate groups that enhance its stability and efficacy within the cellular environment. The compound is typically characterized by its ability to inhibit viral replication by mimicking the building blocks of RNA, leading to the incorporation of the drug into viral RNA and resulting in mutations that hinder viral proliferation. Ribavirin diphosphate is soluble in water, which facilitates its bioavailability in biological systems. Its mechanism of action involves competitive inhibition of viral RNA polymerases and modulation of host immune responses. Overall, ribavirin diphosphate plays a crucial role in antiviral therapy, particularly in combination treatments, due to its ability to enhance the effectiveness of other antiviral agents.
Formula:C8H14N4O11P2
InChI:InChI=1/C8H14N4O11P2/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(22-8)1-21-25(19,20)23-24(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H,19,20)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1
InChI key:InChIKey=HWSPXPQHONXITJ-AFCXAGJDSA-N
SMILES:O[C@H]1[C@@H](O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O)N2N=C(C(N)=O)N=C2
Synonyms:
  • 1-[5-O-[Hydroxy(phosphonooxy)phosphinyl]-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxamide
  • Ribavirin diphosphate
  • 1H-1,2,4-Triazole-3-carboxamide, 1-[5-O-[hydroxy(phosphonooxy)phosphinyl]-β-D-ribofuranosyl]-
  • Ribavirin 5′-diphosphate
  • See more synonyms
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