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CAS 6323-99-5

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2-Amino-4-phosphonobutanoic acid

Description:
2-Amino-4-phosphonobutanoic acid, commonly referred to as APB, is an amino acid derivative characterized by the presence of a phosphonate group. Its chemical structure features a four-carbon backbone with an amino group (-NH2) and a phosphonic acid group (-PO3H2) attached to the second and fourth carbon atoms, respectively. This compound is known for its role as a selective agonist for certain glutamate receptors, particularly the metabotropic glutamate receptor subtype 2 (mGluR2), making it of interest in neuropharmacology and research related to neurological disorders. APB is typically a white crystalline solid and is soluble in water, which facilitates its use in biological studies. Its unique properties stem from the combination of the amino acid structure and the phosphonate moiety, which can influence its reactivity and interactions with biological systems. As a research chemical, it is often utilized in studies investigating synaptic transmission and neuroprotection. Safety and handling precautions should be observed, as with any chemical substance, to mitigate potential hazards.
Formula:C4H10NO5P
InChI:InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
InChI key:InChIKey=DDOQBQRIEWHWBT-UHFFFAOYSA-N
SMILES:C(C(C(O)=O)N)CP(=O)(O)O
Synonyms:
  • 2-Amino-4-phosphonobutyric acid
  • Butyric acid, 2-amino-4-phosphono-
  • Butanoic acid, 2-amino-4-phosphono-
  • 3-Amino-3-carboxypropylphosphonic acid
  • 2-Amino-4-phosphonobutanoic acid
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