CAS 63234-80-0

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Description:

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, with the CAS number 63234-80-0, is a chemical compound that belongs to the class of pyrido-pyrimidines. This substance features a complex bicyclic structure that includes a pyridine and a pyrimidine ring, contributing to its unique chemical properties. The presence of a chloroethyl group enhances its reactivity, making it potentially useful in various chemical reactions, including nucleophilic substitutions. The tetrahydro configuration indicates that the compound is saturated in certain positions, which may influence its biological activity and solubility. Additionally, the methyl group attached to the pyridine ring can affect the compound's sterics and electronic properties. This compound may exhibit pharmacological activities, although specific biological data would be necessary to ascertain its potential applications in medicinal chemistry. Overall, its structural characteristics suggest that it could be of interest in the development of new therapeutic agents or as a building block in organic synthesis.

Formula: C₁₁H₁₅ClN₂O

InChI: InChI=1/C11H15ClN2O/c1-8-9(5-6-12)11(15)14-7-3-2-4-10(14)13-8/h2-7H2,1H3

InChI key: InChIKey=CMWCQQUYLPYOMY-UHFFFAOYSA-N

SMILES: O=C1N2C(=NC(C)=C1CCCl)CCCC2

Synonyms:

• 3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido-(1,2-A) Pyrimidin-4-One
• 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-
• 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
• 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-A]pyrimidin-4-one
• 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2
• 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrididine-4-one (intermediate of Risperidone)
• 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]-PYRIMIDIN-4-ONE(RISPERIDONEINTERMEDIATE)
• -a]pyrimidin-4-one
• 3-2(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimnidin-4-one
• 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDINO[1,2-A]PYRIMIDINE-4-ONE
• 8-(CHLOROETHYL)-9-METHYL-6,10-DIAZABICYCLO[4.4.0]DECA-8,10-DIEN-7-ONE
• 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1, 2-A]-PYRIMIDIN-4-ONE ( RISPERIDONE INTERMEDIATE ).
• 3-2(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]PYRIMDIN-4-ONE
• 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]-PYRIDIDINE-4-ONE
• 3-(2-CHLORO-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
• 3-(2-Chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrimidine-4-one
• 3-(2-CHLOROETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-ALPHA]PYRIMIDIN-4-ONE
• 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRLDO[1,2-A]PYRIMDIN-4-ONE
• 3-(2-CHLOROETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2A)PYRIMIDINE-4-ONE

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

CAS: 63234-80-0

Formula: C₁₁H₁₅ClN₂O

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 226.70

Ref: 3B-C2433

Risperidone Pyridopyrimidinone Analog (3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one)

CAS: 63234-80-0

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₁H₁₅ClN₂O

Color and Shape: Off-White Solid

Molecular weight: 226.08729

Ref: 45-1A11420

Risperidone EP Impurity L

CAS: 63234-80-0

Formula: C₁₁H₁₅ClN₂O

Color and Shape: White To Off-White Solid

Molecular weight: 226.70

Ref: 4Z-R-0633

3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One

CAS: 63234-80-0

3-(2-Chloroethyl)-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One

Purity: 98%

Molecular weight: 226.70g/mol

Ref: 54-OR1010638

Risperidone EP Impurity L

CAS: 63234-80-0

Formula: C₁₁H₁₅ClN₂O

Molecular weight: 263.16

Ref: ST-EA-CP-R15012

3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Controlled Product

CAS: 63234-80-0

Impurity Risperidone EP Impurity L
Applications 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)

Formula: C₁₁H₁₅ClN₂O

Color and Shape: Neat

Molecular weight: 226.70

Ref: TR-C366155

3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

CAS: 63234-80-0

3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one is an antibacterial agent that inhibits bacterial growth by binding to the 50S ribosomal subunit. It is a white crystalline powder that is soluble in methanol and acetonitrile. 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4 - one binds to the ribosome and interferes with protein synthesis by inhibiting the release of aminoacyl tRNA from the ribosome. The drug has been shown to have antibacterial activity against Gram positive and Gram negative bacteria. 3-(2) Chloroethyl)-2-methyl 6,7

Formula: C₁₁H₁₅ClN₂O

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 226.7 g/mol

Ref: 3D-FC20229

3-(2-CHLORO-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]PYRIMIDIN-4-ONE

CAS: 63234-80-0

Formula: C₁₁H₁₅ClN₂O

Purity: 97%

Color and Shape: Solid

Molecular weight: 226.7

Ref: 10-F300981