CAS 63250-09-9

2,3-Dinor-TXB2

Description:

2,3-Dinor-TXB2, with the CAS number 63250-09-9, is a metabolite of thromboxane A2, which is a potent vasoconstrictor and platelet aggregator. This compound is characterized by its structure, which features a cyclopentane ring and multiple functional groups that contribute to its biological activity. As a derivative of thromboxane, 2,3-Dinor-TXB2 plays a role in various physiological processes, particularly in the cardiovascular system, where it influences blood flow and clot formation. Its synthesis occurs through the enzymatic conversion of thromboxane A2, and it is often studied in the context of vascular health and disease. The compound is typically analyzed using techniques such as chromatography and mass spectrometry to understand its concentration and effects in biological samples. Due to its involvement in platelet function and vascular tone regulation, 2,3-Dinor-TXB2 is of interest in research related to thrombosis, cardiovascular diseases, and potential therapeutic interventions.

Formula: C₁₈H₃₀O₆

InChI: InChI=1/C18H30O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,18-20,23H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14?,15-,16+,18+/m0/s1

InChI key: InChIKey=RJHNVFKNIJQTQF-JORIIADHSA-N

SMILES: C(/C=C\CC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)O[C@@H](O)C[C@@H]1O

Synonyms:

• Dinorthromboxane B2
• 3-Pentenoic acid, 5-[tetrahydro-4,6-dihydroxy-2-(3-hydroxy-1-octenyl)-2H-pyran-3-yl]-, [2R-[2α(1E,3S*),3β(Z),4β,6α]]-
• 3-Pentenoic acid, 5-[(2R,3S,4S,6R)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]-2H-pyran-3-yl]-, (3Z)-
• 3-Pentenoic acid, 5-[(2R,3S,4S,6R)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-, (3Z)-
• (3Z)-5-[(2R,3S,4S,6R)-Tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-3-pentenoic acid
• 2,3-DINOR-TXB2
• (E)-5-[(2S,3S,4S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acid
• (5Z,13E,15S)-9α,11,15-Trihydroxy-2,3-dinorthromboxa-5,13-dien-1-oic acid
• RJHNVFKNIJQTQF-LMIBIYGPSA-N
• 2,3-dinor Thromboxane B2 Lipid Maps MS Standard
• 9ALPHA,11,15S-TRIHYDROXY-2,3-DINOR-THROMBA-5Z,13E-DIEN-1-OIC ACID
• 2,3-DINOR THROMBOXANE B2

2,3-dinor Thromboxane B2

CAS: 63250-09-9

Thromboxane B2 (TXB2) is a compound significantly released from aggregating platelets and undergoes metabolic transformation during circulation into 11-dehydro TXB2 and 2,3-dinor TXB2. The latter, 2,3-dinor TXB2, serves as a prevalent urinary metabolite of TXB2 and acts as an indicator for in vivo TXA2 synthesis. Studies have shown that in healthy male volunteers, the median excretion rate of 2,3-dinor TXB2 is measured at 10.3 ng/hour, equivalent to 138 pg/mg of creatinine.

Formula: C₁₈H₃₀O₆

Color and Shape: Solid

Molecular weight: 342.4

Ref: TM-T84626

2,3-Dinor Thromboxane B2

CAS: 63250-09-9

Formula: C₁₈H₃₀O₆

Molecular weight: 342.43

Ref: 4Z-T-729