CAS 63409-12-1

Tylvalosin

Description:

Tylvalosin is a macrolide antibiotic primarily used in veterinary medicine, particularly for treating respiratory infections in livestock and poultry. It is derived from the fermentation of certain actinomycetes and is known for its effectiveness against a range of Gram-positive bacteria and some Gram-negative bacteria. The chemical structure of tylvalosin features a large lactone ring, which is characteristic of macrolides, contributing to its antibacterial properties. It is typically administered in feed or water formulations, making it convenient for large-scale animal treatment. Tylvalosin acts by inhibiting bacterial protein synthesis, thereby preventing the growth and reproduction of bacteria. Its pharmacokinetics indicate good absorption and distribution in animal tissues, although its use is regulated in food-producing animals to ensure that residues do not enter the human food supply. As with many antibiotics, there is a concern regarding the development of antibiotic resistance, prompting careful consideration of its use in veterinary practices.

Formula: C₅₃H₈₇NO₁₉

InChI: InChI=1S/C53H87NO19/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3/b18-17+,28-22+/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-/m1/s1

InChI key: InChIKey=KCJJINQANFZSAM-HZDSEHBESA-N

SMILES: O([C@H]1[C@H](N(C)C)[C@@H](O)[C@H](O[C@H]2[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](OC(C)=O)[C@@H]2C)O[C@@H]1C)[C@H]4C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O4

Synonyms:

• (4R,5S,6S,7R,9R,11E,13E,15R,16R)-15-(((6-Deoxy-2,3-di-O-methyl-beta-D-allopyranosyl)oxy)methyl)-6-((3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl)oxy)-16-ethyl-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
• (4R,5S,6S,7R,9R,11E,13E,15R,16R)-15-{[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl}-6-({3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-α-L-ribo-hexopyranosyl]-3-(dimethylamino)-β-D-glucopyranosyl}oxy)-16-ethyl-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
• 3-Acetyl-4''-isovaleryltylosin
• 3-O-Acetyl-4′′-O-isovaleryltylosin
• Acetylisovaleryltylosin
• Oxacyclohexadecane, tylosin deriv.
• Tylosin, 3-acetate 4^B-(3-methylbutanoate)
• Tylvalosin
• Tylvalosin [USAN]
• Tylosin, 3-acetate 4B-(3-methylbutanoate)

Tylvalosin (Acetylisovaleryltylosin)

CAS: 63409-12-1

Formula: C₅₃H₈₇NO₁₉

Color and Shape: White To Off-White Solid

Molecular weight: 1042.27

Ref: 4Z-T-175003

Tylvalosin 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 63409-12-1

Formula: C₅₃H₈₇NO₁₉

Color and Shape: Colourless

Molecular weight: 1042.25

Ref: 04-A17895650AL-1000

Tylvalosin-d9

CAS: 63409-12-1

Formula: C₅₃H₇₈D₉NO₁₉

Molecular weight: 1051.32

Ref: 4Z-T-175005

Tylvalosin (>90%)

CAS: 63409-12-1

Formula: C₅₃H₈₇NO₁₉

Purity: >90%

Color and Shape: Neat

Molecular weight: 1042.25

Ref: TR-T898211

Tylvalosin-d9

Controlled Product

CAS: 63409-12-1

Applications Tylvalosin-d9 is the labeled analogue of Tylvalosin (T898210), an anti-bacterial agent that is shown through study as a good inhibitor of gram-positive bacteria.
References Okamoto, R. et al.: J. Antibio., 32, 542 (1979)

Formula: C₅₃D₉H₇₈NO₁₉

Purity: >90%

Color and Shape: Light Yellow Solid

Molecular weight: 1051.31

Ref: TR-T898212

Tylvalosin

CAS: 63409-12-1

Tylvalosin is a polymerase chain inhibitor that inhibits the activity of the bacterial DNA polymerase. It is used in antimicrobial treatment to prevent microbial infection due to its immunomodulatory effects. Tylvalosin is active against a wide range of microorganisms and has been shown to be effective against infections caused by bacteria such as Haemophilus influenzae, Streptococcus pyogenes, and Staphylococcus aureus. The drug also has anti-inflammatory properties and can be used for the treatment of synovitis, an inflammation of the synovium. Tylvalosin is not active against Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₅₃H₈₇NO₁₉

Purity: (%) Min. 90%

Color and Shape: Powder

Molecular weight: 1,042.25 g/mol

Ref: 3D-FT158429

Tylvalosin

CAS: 63409-12-1

Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection.

Formula: C₅₃H₈₇NO₁₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 1042.25

Ref: TM-T78113