CAS 63442-81-9

Dityrosine

Description:

Dityrosine is a dipeptide formed by the oxidative coupling of two tyrosine molecules, characterized by the presence of a covalent bond between the phenolic groups of the amino acids. It is typically found in proteins and is known for its role in the formation of cross-links, which can enhance the stability and structural integrity of proteins. Dityrosine exhibits unique fluorescence properties, making it a useful marker in biochemical studies, particularly in the context of oxidative stress and protein aggregation. The substance is soluble in water and exhibits a relatively high melting point. Its formation is often associated with various physiological processes, including the response to oxidative stress, and it has been implicated in certain pathological conditions, such as neurodegenerative diseases. The presence of dityrosine can be detected using spectroscopic methods, which can provide insights into protein modifications and the state of cellular health. Overall, dityrosine serves as an important biomarker in both research and clinical settings.

Formula: C₁₈H₂₀N₂O₆

Synonyms:

• o,o'-Dityrosine
• L,L-Dityrosine
• [1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, (α3S,α3'S)-
• Dityrosine USP/EP/BP
• (2S,2'S)-3,3'-(6,6'-dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-aminopropanoic acid)

(2S,2'S)-3,3'-(6,6'-Dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-aminopropanoic acid)

CAS: 63442-81-9

(2S,2'S)-3,3'-(6,6'-Dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-aminopropanoic acid)

Purity: 99%

Molecular weight: 360.37g/mol

Ref: 54-OR1074627

L,L-Dityrosine

CAS: 63442-81-9

L,L-Dityrosine, a component found in the acid hydrolysates of various biological materials, such as insect cuticular resilin, plays a significant role in

Formula: C₁₈H₂₀N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.36

Ref: TM-T19396

L,L-Dityrosine

CAS: 63442-81-9

L,L-Dityrosine is a byproduct of the enzymatic breakdown of proteins. It can be detected in biological samples such as urine, plasma and serum using an antibody that recognizes the Dityrosine amino acid sequence. L,L-Dityrosine can also be used to measure radiation exposure. The signal peptide is cleaved from the protein when it is exposed to radiation and L,L-Dityrosine accumulates. This signal peptide is then removed by proteases and L,L-Dityrosine levels return to normal. L,L-Dityrosine has been shown to inhibit the growth of atherosclerotic lesions in experimental models and may be a potential biomarker for oxidative injury in alveolar type II cells. In addition, this compound has conformational properties that are similar to those found on proteins associated with Alzheimer's disease (AD) and other neurological disorders.END>

Formula: C₁₈H₂₀N₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 360.4 g/mol

Ref: 3D-NCA44281