CAS 634907-30-5

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine

Description:

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine, commonly referred to as D4T or stavudine, is an antiretroviral medication primarily used in the treatment of HIV/AIDS. This compound is a nucleoside reverse transcriptase inhibitor (NRTI) that mimics the structure of thymidine, allowing it to interfere with viral replication by inhibiting the reverse transcriptase enzyme. Its chemical structure features a modified thymidine backbone, with a dehydro and deoxy configuration at the 2′ and 3′ positions, and an ethynyl group at the 4′ position, which enhances its antiviral activity. D4T is characterized by its ability to penetrate cells effectively and its relatively low toxicity profile compared to other NRTIs. However, it can be associated with side effects such as peripheral neuropathy and lactic acidosis. The compound is typically administered orally and is often part of combination therapy regimens to improve treatment efficacy and reduce the risk of resistance development.

Formula: C₁₂H₁₂N₂O₄

InChI: InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1

InChI key: InChIKey=OSYWBJSVKUFFSU-SKDRFNHKSA-N

SMILES: C(#C)[C@]1(CO)O[C@H](C=C1)N2C(=O)NC(=O)C(C)=C2

Synonyms:

• Censavudine
• Thymidine, 2′,3′-didehydro-3′-deoxy-4′-ethynyl-
• 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine
• 4′-Ed4T
• BMS 986001

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine

CAS: 634907-30-5

Formula: C₁₂H₁₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 248.2347

Ref: IN-DA01NVHB

Censavudine

CAS: 634907-30-5

Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.

Formula: C₁₂H₁₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 248.23

Ref: TM-T30791

Festinavir

Controlled Product

CAS: 634907-30-5

Formula: C₁₂H₁₂N₂O₄

Color and Shape: Neat

Molecular weight: 248.235

Ref: TR-F321325

Censavudine

CAS: 634907-30-5

Censavudine is an antiviral compound, which is a synthetic nucleoside analog designed to interfere with viral replication processes. The source of this compound lies in its chemical synthesis, which involves precise structural modifications to resemble natural nucleosides. Its mode of action involves incorporation into viral RNA by the viral polymerase, leading to chain termination. This mechanism effectively hinders the replication of viral genomes, thus preventing the proliferation of the virus within the host organism.

Formula: C₁₂H₁₂N₂O₄

Purity: Min. 95%

Molecular weight: 248.23 g/mol

Ref: 3D-JAB90730