CAS 63521-85-7

Esorubicin

Description:

Esorubicin is an anthracycline antibiotic that is primarily used in cancer therapy, particularly for treating various types of leukemia and solid tumors. It is structurally related to doxorubicin and exhibits similar mechanisms of action, primarily through intercalation into DNA, which inhibits DNA and RNA synthesis, ultimately leading to cell death. Esorubicin is known for its ability to generate free radicals, contributing to its cytotoxic effects. The compound has a molecular formula that includes carbon, hydrogen, oxygen, and nitrogen, reflecting its complex structure. It is typically administered intravenously and has a specific pharmacokinetic profile, including metabolism primarily in the liver and excretion through the kidneys. While effective, esorubicin can also have side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. Its use is often limited by these potential adverse effects, and it is usually reserved for cases where other treatments have failed or are not suitable. Overall, esorubicin remains an important agent in the oncological pharmacotherapy arsenal.

Formula: C₂₇H₂₉NO₁₀

InChI: InChI=1/C27H29NO10/c1-11-6-12(28)7-18(37-11)38-16-9-27(35,17(30)10-29)8-14-20(16)26(34)22-21(24(14)32)23(31)13-4-3-5-15(36-2)19(13)25(22)33/h3-5,11-12,16,18,29,32,34-35H,6-10,28H2,1-2H3/t11-,12+,16-,18-,27-/m0/s1

InChI key: InChIKey=ITSGNOIFAJAQHJ-BMFNZSJVSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)C[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

Synonyms:

• (8R,10R)-10-[(4-amino-6-methyltetrahydro-2H-pyran-2-yl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
• (8S,10S)-10-[[(2S,4R,6S)-4-Aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
• (8S,10S)-10-{[(2S,4R,6S)-4-amino-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
• 4'-Deoxyadriamycin
• 4'-Deoxydoxorubicin
• 5,12-Naphthacenedione, 10-(((2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 10-((4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (2S-(2alpha(8R*10R*),4beta,6beta))-
• 5,12-Naphthacenedione, 10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, [2S-[2α(8R*,10R*),4β,6β]]-
• 5,12-Naphthacenedione, 10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((tetrahydro-4-amino-6-methyl-2H-pyran-2-yl)oxy)-8-glycoloyl-1-methoxy-6,8,11-trihydroxy-
• Brn 1415739
• Ccris 5426
• Deoxydoxorubicin
• Esorubicin [INN]
• Esorubicina
• Esorubicina [INN-Spanish]
• Esorubicine
• Esorubicine [INN-French]
• Esorubicinum
• Esorubicinum [INN-Latin]

Esorubicin

CAS: 63521-85-7

Esorubicin, a doxorubicin derivative, intercalates DNA, inhibits topoisomerase II, has less cardiotoxicity, but more myelosuppression.

Formula: C₂₇H₂₉NO₁₀

Color and Shape: Solid

Molecular weight: 527.52

Ref: TM-T68961