CAS 63527-53-7: (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Description: The chemical substance with the name "(6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" and CAS number "63527-53-7" is a complex bicyclic compound that belongs to the class of antibiotics known as cephalosporins. It features a thiazole ring, which contributes to its biological activity, particularly against bacterial infections. The presence of an acetyloxy group suggests potential for enhanced stability and bioavailability. This compound exhibits a broad spectrum of antibacterial activity, primarily targeting Gram-positive and some Gram-negative bacteria. Its mechanism of action typically involves the inhibition of bacterial cell wall synthesis, leading to cell lysis and death. The stereochemistry indicated by the (6R,7R) configuration is crucial for its pharmacological properties, influencing both its efficacy and safety profile. Overall, this substance represents a significant advancement in antibiotic development, aimed at combating resistant bacterial strains.

Formula: C₁₆H₁₇N₅O₇S₂

InChI: InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9+/t10-,14-/m1/s1

InChI key: InChIKey=GPRBEKHLDVQUJE-VINNURBNSA-N

SMILES: O=C(O)C1=C(COC(=O)C)CSC2N1C(=O)C2NC(=O)C(=NOC)C=3N=C(SC3)N

Synonyms:

• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
• R 02-5328A
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2E)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
• (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7β(E)]]-

(E)-Cefotaxime

CAS: 63527-53-7

• Formula: C₁₆H₁₇N₅O₇S₂
• Color and Shape: Neat
• Molecular weight: 455.466

(E)-Cefotaxime

CAS: 63527-53-7

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• Formula: C₁₆H₁₇N₅O₇S₂
• Purity: Min. 95%
• Molecular weight: 455.5 g/mol