CAS 635702-64-6

Pazopanib hydrochloride

Description:

Pazopanib hydrochloride is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including renal cell carcinoma and soft tissue sarcoma. It functions by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis. The substance is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, oxygen, and chlorine atoms, reflecting its complex structure. Pazopanib hydrochloride is typically administered orally and is known for its moderate to high solubility in various solvents, which facilitates its absorption in the gastrointestinal tract. The compound exhibits a relatively long half-life, allowing for once-daily dosing in clinical settings. Common side effects associated with its use may include hypertension, diarrhea, and fatigue, among others. As with many targeted therapies, monitoring for adverse effects and drug interactions is essential during treatment. Overall, pazopanib hydrochloride represents a significant advancement in targeted cancer therapy, providing a mechanism to inhibit tumor progression effectively.

Formula: C₂₁H₂₃N₇O₂S·ClH

InChI: InChI=1/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H

InChI key: InChIKey=MQHIQUBXFFAOMK-UHFFFAOYSA-N

SMILES: CC1=C2C(C=C(N(C)C3=NC(NC4=CC(S(N)(=O)=O)=C(C)C=C4)=NC=C3)C=C2)=NN1C.Cl

Synonyms:

• 5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochloride
• 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(Methyl)amino)pyrimidin-2-ylamino)-2-Methylbenzenesulfonamide hydrochloride
• 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochloride
• Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-,monohydrochloride
• Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, hydrochloride (1:1)
• Gw 786034B
• Gw786034B
• Pazopanib HCl
• Unii-33Y9Anm545
• Votrient
• Pazopanib hydrochloride
• ArMala
• Pazopanib HCl (GW786034 HCl)
• Pazopanib Hydrochloride (GW786034)
• 786034
• Pazopanib HCI

Pazopanib Hydrochloride

CAS: 635702-64-6

Sulfonamides used as drugs

Formula: C₂₁H₂₃N₇O₂S·HCl

Color and Shape: White Pale Yellow Solid

Molecular weight: 437.16339

Ref: 45-1500491

Pazopanib Hydrochloride

CAS: 635702-64-6

Pazopanib Hydrochloride

Purity: ≥98%

Molecular weight: 473.98g/mol

Ref: 54-BUP15707

Pazopanib Hydrochloride

CAS: 635702-64-6

Pazopanib Hydrochloride

Purity: 98%

Molecular weight: 473.987g/mol

Ref: 54-OR1029257

Pazopanib HCl

CAS: 635702-64-6

Formula: C₂₁H₂₃N₇O₂S·HCl

Molecular weight: 437.52 36.46

Ref: 4Z-P-129035

Pazopanib Hydrochloride

CAS: 635702-64-6

Formula: C₂₁H₂₃N₇O₂S·HCl

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 473.98

Ref: 3B-P2243

Pazopanib Hydrochloride

CAS: 635702-64-6

Color and Shape: Neat

Ref: 86-MM3391.00

Pazopanib hydrochloride

CAS: 635702-64-6

Formula: C₂₁H₂₄ClN₇O₂S

Purity: ≥ 98.0% (dried basis)

Color and Shape: White or off-white powder

Molecular weight: 473.98

Ref: 7W-GX4287

GW786034B

CAS: 635702-64-6

Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.

Formula: C₂₁H₂₃N₇O₂S·HCl

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 473.98

Ref: TM-T6930

Pazopanib Hydrochloride

Controlled Product

CAS: 635702-64-6

Applications The Hydrochloride salt of Pazopanib (P210925) a oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

Formula: C₂₁H₂₃N₇O₂S·ClH

Color and Shape: Off-White

Molecular weight: 473.98

Ref: TR-P210926

Pazopanib-d3 Hydrochloride

Controlled Product

CAS: 635702-64-6

Applications Pazopanib-d3 is the isotope labelled analog of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

Formula: C₂₁H₂₁D₃ClN₇O₂S

Color and Shape: Neat

Molecular weight: 477.0

Ref: TR-P210927

Pazopanib, Hydrochloride Salt

CAS: 635702-64-6

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 473.9800109863281

Ref: 10-F519777

Pazopanib HCl - Bio-X ™

CAS: 635702-64-6

Pazopanib is an antineoplastic agent that is used to treat advanced renal cell cancer and advanced soft tissues sarcoma. This drug is a multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor 1, 2, 3 and c-kit. As a result, it increases tumor apoptosis and decreases tumor blood flow.

Formula: C₂₁H₂₃N₇O₂S•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 473.98 g/mol

Ref: 3D-BP166746

Pazopanib HCl

CAS: 635702-64-6

Multitargeted tyrosine kinase inhibitor; angiogenesis inhibitor

Formula: C₂₁H₂₃N₇O₂S·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 473.98 g/mol

Ref: 3D-FD71644