CAS 636-47-5

Distamycin A

Description:

Distamycin A is a naturally occurring antibiotic and antitumor agent, classified as a member of the distamycin family of compounds. It is characterized by its unique structure, which includes a pyrrole-based backbone that contributes to its biological activity. Distamycin A exhibits a strong affinity for DNA, particularly binding to the minor groove of the double helix, which influences gene expression and can inhibit the growth of certain cancer cells. This compound is known for its selective cytotoxicity, making it a subject of interest in cancer research. Additionally, Distamycin A has been studied for its potential use in molecular biology as a probe for DNA and RNA due to its ability to interact with nucleic acids. Its solubility properties and stability under physiological conditions are also notable, although it may exhibit varying degrees of activity depending on the specific cellular environment. Overall, Distamycin A represents a significant compound in the study of antibiotic and anticancer therapies.

Formula: C₂₂H₂₇N₉O₄

InChI: InChI=1S/C22H27N9O4/c1-29-9-13(26-12-32)6-17(29)21(34)28-15-8-18(31(3)11-15)22(35)27-14-7-16(30(2)10-14)20(33)25-5-4-19(23)24/h6-12H,4-5H2,1-3H3,(H3,23,24)(H,25,33)(H,26,32)(H,27,35)(H,28,34)

InChI key: InChIKey=UPBAOYRENQEPJO-UHFFFAOYSA-N

SMILES: C(NC=1C=C(C(NCCC(=N)N)=O)N(C)C1)(=O)C2=CC(NC(=O)C3=CC(NC=O)=CN3C)=CN2C

Synonyms:

• Stallimycin
• Distamycin A
• N,4′:N′,4′′-Ter[pyrrole-2-carboxamide], N′′-(2-amidinoethyl)-4-formamido-1,1′,1′′-trimethyl-
• 1H-Pyrrole-2-carboxamide, N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-
• N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide

Distamycin A

CAS: 636-47-5

Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.

Formula: C₂₂H₂₇N₉O₄

Color and Shape: Solid

Molecular weight: 481.51

Ref: TM-T73730