CAS 63659-18-7

Betaxolol

Description:

Betaxolol is a selective beta-1 adrenergic antagonist primarily used in the treatment of hypertension and certain types of glaucoma. As a member of the beta-blocker class, it works by blocking the action of epinephrine on beta-1 receptors in the heart, leading to a decrease in heart rate and cardiac output, which helps lower blood pressure. Betaxolol is characterized by its relatively high selectivity for beta-1 receptors over beta-2 receptors, making it less likely to cause bronchoconstriction, a common side effect associated with non-selective beta-blockers. The substance is typically administered orally or as an ophthalmic solution, with its pharmacokinetics influenced by factors such as absorption, distribution, metabolism, and excretion. Betaxolol is known for its favorable side effect profile, but like all medications, it may cause adverse effects in some patients, including fatigue, dizziness, or bradycardia. Its chemical structure includes a phenoxypropanolamine moiety, contributing to its pharmacological properties.

Formula: C₁₈H₂₉NO₃

InChI: InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3

InChI key: InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(CCOCC2CC2)C=C1

Synonyms:

• 2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-
• 1-Isopropylamino-3-[4-(2-cyclopropylmethoxy-ethyl)phenoxy]-2-propanol
• Betaxolol
• Betoptic S
• 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol

Betaxolol Hydrochloride

CAS: 63659-18-7, 63659-19-8

Formula: C₁₈H₂₉NO₃·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 343.89

Ref: 3B-B4474

Betaxolol HCl

CAS: 63659-18-7

Formula: C₁₈H₂₉NO₃·HCl

Molecular weight: 307.44 36.46

Ref: 4Z-B-141

Betaxolol

CAS: 63659-18-7

Betaxolol (Kerlone) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Formula: C₁₈H₂₉NO₃

Purity: 99.01%

Color and Shape: White Crystalline Solid

Molecular weight: 307.43

Ref: TM-T6408

Betaxolol Impurity 4 HCl

CAS: 63659-18-7

Formula: C₁₄H₂₃NO₂·HCl

Molecular weight: 237.34 36.46

Ref: 4Z-B-1412

Betaxolol

CAS: 63659-18-7

Applications Cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma.
References Cadigan, P.J., et al.: Br. J. Clin. Pharmacol., 9, 569 (1980), Pathe, M., et al.: Therapie, 37, 75 (1982),

Formula: C₁₈H₂₉NO₃

Color and Shape: Off-White

Molecular weight: 307.43

Ref: TR-B328000

Betaxolol

Controlled Product

CAS: 63659-18-7

Betaxolol is a cardioselective beta-adrenergic blocker that has been shown to reduce intraocular pressure in patients with primary open-angle glaucoma. It is also used for the treatment of cardiac arrhythmias and high blood pressure. Betaxolol is an ester prodrug that is hydrolyzed by esterases to its active form, betaxolol hydrochloride (BXH). Betaxolol hydrochloride has a significant cytotoxic effect on cells through inhibition of DNA synthesis. A majority of BXH is eliminated from the body unchanged via renal excretion, however some BXH is metabolized by cytochrome P450 enzymes to inactive metabolites. The pharmacokinetics of this drug can be monitored by measuring plasma concentrations of betaxolol and betaxolol hydrochloride. Betaxolol may be determined by analytical methods such as x-ray diffraction data and electrochemical impedance

Formula: C₁₈H₂₉NO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 307.43 g/mol

Ref: 3D-FB160758

Betaxolol

CAS: 63659-18-7

Formula: C₁₈H₂₉NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.4278

Ref: IN-DA00E8UZ