CAS 63661-61-0

Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-, hydrochloride (1:1)

Description:

Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-, hydrochloride (1:1), with the CAS number 63661-61-0, is a chemical compound that belongs to the class of piperidine derivatives. It features a piperidine ring, which is a six-membered saturated heterocycle containing one nitrogen atom. The compound is characterized by the presence of a tert-butyl group (1,1-dimethylethyl) and two phenyl groups attached to the piperidine ring, contributing to its unique structural and chemical properties. As a hydrochloride salt, it is typically encountered in a solid form, which enhances its stability and solubility in polar solvents. This compound may exhibit biological activity, making it of interest in medicinal chemistry and pharmacology. Its properties, such as melting point, solubility, and reactivity, can vary based on the specific conditions and the presence of other substances. Safety data should be consulted for handling and usage, as with all chemical substances.

Formula: C₂₁H₂₇N·ClH

InChI: InChI=1S/C21H27N.ClH/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19;/h4-13H,14-17H2,1-3H3;1H

InChI key: InChIKey=USUUKNCFNKZGEY-UHFFFAOYSA-N

SMILES: C(C)(C)(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3.Cl

Synonyms:

• 1-(1,1-Dimethylethyl)-4,4-diphenylpiperidine hydrochloride
• 1-tert-Butyl-4,4-diphenylpiperidiniumchloride
• Budipine hydrochloride
• By-701
• Parkinsan
• Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-, hydrochloride
• Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-, hydrochloride (1:1)

Budipine hydrochloride

CAS: 63661-61-0

Budipine hydrochloride is a potent, selective and long-acting inhibitor of the enzyme catechol-O-methyltransferase (COMT) that is used as a treatment for Parkinson's disease. It has been shown to inhibit dopamine breakdown by COMT. This inhibition leads to increased concentrations of dopamine in the brain, which are thought to have neurotrophic effects. Budipine hydrochloride also has antioxidative properties, which may help protect neurons from oxidative stress. The drug has been shown to cause neuronal death in animals, but not humans. Further research is needed on the effects of budipine hydrochloride on other neurotransmitters and receptors in the central nervous system.

Formula: C₂₁H₂₈ClN

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 329.91 g/mol

Ref: 3D-FB172928

Budipine Hydrochloride

CAS: 63661-61-0

Budipine is an antiparkinsonian that enhances dopamine release, inhibits MAO-B, blocks dopamine reuptake, and stimulates AADC.

Formula: C₂₁H₂₈ClN

Purity: 98%

Color and Shape: Solid

Molecular weight: 329.91

Ref: TM-T7626L