CAS 63675-72-9

Nisoldipine

Description:

Nisoldipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. Nisoldipine is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. The compound typically exhibits a long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Nisoldipine is generally well-tolerated, but like other calcium channel blockers, it may cause side effects such as peripheral edema, headache, and flushing. It is important to monitor patients for potential interactions with other medications, as well as to assess renal and hepatic function during treatment. Overall, nisoldipine is an effective option for managing cardiovascular conditions, contributing to improved patient outcomes in hypertension management.

Formula: C₂₀H₂₄N₂O₆

InChI: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3

InChI key: InChIKey=VKQFCGNPDRICFG-UHFFFAOYSA-N

SMILES: C(OCC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(N(=O)=O)C=CC=C2

Synonyms:

• (.+-.)-BAY k 5552
• (.+-.)-Nisoldipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-methylpropyl) ester
• 3-Methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-O-Methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Baymycard
• Geomatrix 16E
• Nisocor
• Nisoldipin
• Nisoldipino
• Norvasc
• Sular
• Syscor
• Zadipina
• 2,6-Dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
• 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-Methylpropyl Ester
• methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester
• Isobutyl 1,4-Dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylate
• Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
• Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester

Nisoldipine

CAS: 63675-72-9

Formula: C₂₀H₂₄N₂O₆

Purity: >98.0%(HPLC)(N)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 388.42

Ref: 3B-N0900

Nisoldipine, 98%

CAS: 63675-72-9

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Formula: C₂₀H₂₄N₂O₆

Purity: 98%

Color and Shape: White to yellow, Crystalline powder

Molecular weight: 388.42

Ref: 02-H37972

Nisoldipine

CAS: 63675-72-9

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₀H₂₄N₂O₆

Color and Shape: Powder

Molecular weight: 388.16344

Ref: 45-1463927

3,​5-​Pyridinedicarboxylic acid, 1,​4-​dihydro-​2,​6-​dimethyl-​4-​(2-​nitrophenyl)​-​, 3-​methyl 5-​(2-​methylpropyl) ester

CAS: 63675-72-9

Formula: C₂₀H₂₄N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 388.4144

Ref: IN-DA003T4E

Nisoldipine

CAS: 63675-72-9

Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.

Formula: C₂₀H₂₄N₂O₆

Purity: 98.79% - 99.57%

Color and Shape: Solid

Molecular weight: 388.41

Ref: TM-T0163

Nisoldipine

CAS: 63675-72-9

Formula: C₂₀H₂₄N₂O₆

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: Pale yellow to yellow powder

Molecular weight: 388.41

Ref: 7W-GP4494

Nisoldipine

CAS: 63675-72-9

Nisoldipine

Purity: ≥98%

Molecular weight: 388.41g/mol

Ref: 54-BUP17375

Nisoldipine

CAS: 63675-72-9

Formula: C₂₀H₂₄N₂O₆

Color and Shape: Yellow Solid

Molecular weight: 388.42

Ref: 4Z-N-091

Nisoldipine

CAS: 63675-72-9

Nisoldipine

Purity: 99%

Molecular weight: 388.41g/mol

Ref: 54-OR1028769

Nisoldipine

CAS: 63675-72-9

Color and Shape: Neat

Ref: 86-MM3912.00

Nisoldipine 100 µg/mL in Methanol

Controlled Product

CAS: 63675-72-9

Formula: C₂₀H₂₄N₂O₆

Color and Shape: Single Solution

Molecular weight: 388.41

Ref: 04-A15530500ME-100

Nisoldipine

Controlled Product

CAS: 63675-72-9

Applications Dihydropyridine calcium channel blocker. Antihypertensive and antianginal.
References Kazda, S., et al.: Arzneimittel-Forsch., 30, 2144 (1980), Pasanisi, F., et al.: Eur. J. Clin. Pharmacol., 29, 21 (1985), Lam, J., et al.: J. Am. Col. Cardiol., 6, 447 (1985)

Formula: C₂₀H₂₄N₂O₆

Color and Shape: Yellow

Molecular weight: 388.41

Ref: TR-N489125

Nisoldipine - Bio-X ™

CAS: 63675-72-9

Nisoldipine is a calcium channel blocker that is used to treat hypertension. It acts on vascular smooth muscle cells by blocking voltage-gated L-type calcium channels. By inhibiting the influx of calcium in smooth muscle cells, Nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.

Formula: C₂₀H₂₄N₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 388.41 g/mol

Ref: 3D-BN164147

Nisoldipine

CAS: 63675-72-9

Calcium channel blocker

Formula: C₂₀H₂₄N₂O₆

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 388.41 g/mol

Ref: 3D-FN26228

NISOLDIPINE

CAS: 63675-72-9

Purity: 97%

Molecular weight: 388.4200134

Ref: 10-F794980