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CAS 63675-72-9

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Nisoldipine

Description:
Nisoldipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. Nisoldipine is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. The compound typically exhibits a long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Nisoldipine is generally well-tolerated, but like other calcium channel blockers, it may cause side effects such as peripheral edema, headache, and flushing. It is important to monitor patients for potential interactions with other medications, as well as to assess renal and hepatic function during treatment. Overall, nisoldipine is an effective option for managing cardiovascular conditions, contributing to improved patient outcomes in hypertension management.
Formula:C20H24N2O6
InChI:InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChI key:InChIKey=VKQFCGNPDRICFG-UHFFFAOYSA-N
SMILES:C(OCC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(N(=O)=O)C=CC=C2
Synonyms:
  • (.+-.)-BAY k 5552
  • (.+-.)-Nisoldipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-methylpropyl) ester
  • 3-Methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 3-O-Methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Baymycard
  • Geomatrix 16E
  • Nisocor
  • Nisoldipin
  • Nisoldipino
  • See more synonyms
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