CAS 6379-56-2

Hygromycin

Description:

Hygromycin is an aminoglycoside antibiotic that is primarily used as a selective agent in molecular biology and microbiology. It is derived from the bacterium *Streptomyces hygroscopicus* and is known for its ability to inhibit protein synthesis by binding to the 30S ribosomal subunit, thereby interfering with the translation process in both prokaryotic and eukaryotic cells. Hygromycin is effective against a variety of bacteria and fungi, making it a valuable tool for researchers in genetic engineering and cell culture. The compound is typically used in concentrations that allow for the selection of genetically modified organisms that have acquired resistance to it, often through the introduction of specific resistance genes. Hygromycin is soluble in water and exhibits stability under a range of pH conditions, although it should be stored properly to maintain its efficacy. Safety precautions should be taken when handling hygromycin, as it can be toxic to humans and other organisms at high concentrations.

Formula: C₂₃H₂₉NO₁₂

InChI: InChI=1/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17-,18-,19+,20+,21-,23+/m0/s1

InChI key: InChIKey=YQYJSBFKSSDGFO-IIHALWDASA-N

SMILES: O[C@H]1[C@]2([C@@]([C@H](O)[C@@H](O)[C@H]1NC(/C(=C/C3=CC(O)=C(O[C@@H]4O[C@H](C(C)=O)[C@@H](O)[C@@H]4O)C=C3)/C)=O)(OCO2)[H])[H]

Synonyms:

• D-neo-Inositol, 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1,2-O-methylene-
• D-neo-Inositol, 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-
• Hygromycin
• D-neo-Inositol, 5-deoxy-5-[[3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1,2-O-methylene-, (E)-
• Homomycin
• Antibiotic WS-1627B
• hygromycin A
• 5-Deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-5-hexosulofuranosyl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1-O,2-O-methylene-D-neo-inositol
• Homomycin A

(E)-3-(4-(((2S,3S,4S,5S)-5-Acetyl-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-3-hydroxyphenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxyhexahydrobenzo[d][1,3]dioxol-5-yl)acrylamide

CAS: 6379-56-2

(E)-3-(4-(((2S,3S,4S,5S)-5-Acetyl-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-3-hydroxyphenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxyhexahydrobenzo[d][1,3]dioxol-5-yl)acrylamide

Purity: 95%

Molecular weight: 511.48g/mol

Ref: 54-OR1053215

Hygromycin A

CAS: 6379-56-2

Formula: C₂₄H₃₁NO₁₁

Molecular weight: 509.51

Ref: 4Z-H-062001

Hygromycin A

CAS: 6379-56-2

Hygromycin A is an antimicrobial compound isolated from the bacterium *Streptomyces hygroscopicus*. It functions by inhibiting protein synthesis within microbial cells. This compound disrupts the elongation phase of translation by binding to the ribosomal subunit, therefore impeding mRNA decoding during protein assembly.

Formula: C₂₃H₂₉NO₁₂

Purity: Min. 95%

Molecular weight: 511.5 g/mol

Ref: 3D-AH183380