CAS 63800-01-1

Pyridinoline

Description:

Pyridinoline is a cross-linking compound primarily found in collagen, which is a crucial structural protein in connective tissues. It is classified as a pyridinium compound and is notable for its role in the stabilization of collagen fibers, contributing to the mechanical strength and integrity of tissues. Pyridinoline is often used as a biomarker for bone turnover and collagen degradation, making it significant in clinical studies related to osteoporosis and other bone-related diseases. The substance is typically present in urine and can be measured to assess bone metabolism. Its structure features a pyridine ring, which is a six-membered aromatic ring containing one nitrogen atom, contributing to its unique chemical properties. Pyridinoline is soluble in water and exhibits fluorescence, which can be utilized in various analytical techniques. Overall, its importance in both biological systems and clinical diagnostics underscores its relevance in the fields of biochemistry and medicine.

Formula: C₁₈H₂₈N₄O₈

InChI: InChI=1S/C18H28N4O8/c19-12(16(25)26)3-1-9-6-22(7-10(23)2-4-13(20)17(27)28)8-15(24)11(9)5-14(21)18(29)30/h6,8,10,12-14,23H,1-5,7,19-21H2,(H3-,24,25,26,27,28,29,30)/t10-,12+,13+,14+/m1/s1

InChI key: InChIKey=LCYXYLLJXMAEMT-SAXRGWBVSA-N

SMILES: C(C[C@@H](C(O)=O)N)C=1C(C[C@@H](C(O)=O)N)=C(O)C=[N+](C[C@@H](CC[C@@H](C([O-])=O)N)O)C1

Synonyms:

• Pyridinium, 4-[(2S)-2-amino-2-carboxyethyl]-1-[(2R,5S)-5-amino-5-carboxy-2-hydroxypentyl]-3-[(3S)-3-amino-3-carboxypropyl]-5-hydroxy-, inner salt
• Pyridinoline
• Hydroxylysylpyridinoline
• L-erythro-Hexonic acid, 2-amino-6-[4-[(2S)-2-amino-2-carboxyethyl]-3-[(3S)-3-amino-3-carboxypropyl]-5-hydroxypyridinio]-2,3,4,6-tetradeoxy-, inner salt

Pyridinoline

CAS: 63800-01-1

Formula: C₁₈H₂₈N₄O₈

Color and Shape: Pale Yellow Solid

Molecular weight: 428.44

Ref: 4Z-P-10802

Hydroxylysylpyridinoline

CAS: 63800-01-1

Stability Hygroscopic
Applications Hydroxylysylpyridinoline, is a derivative of Pyridinoline, which is a is a fluorescent cross-linking compound of collagen fibers. It is also found to beto be released into the blood during bone degradation, and thus there are proposed as a marker for metastatic bone tumor in patients with prostate cancer.
References Gallop, PM., et al.: Annu. Rev. Biochem., 41, 617 (1972); Fujimoto, D., et al.: Biochem. Biophys. Rese. Comm., 76, 1124 (1977);

Formula: C₁₈H₂₈N₄O₈

Color and Shape: Neat

Molecular weight: 428.44

Ref: TR-H954036

Hydroxylysylpyridinoline-d6 (major)

Controlled Product

CAS: 63800-01-1

Formula: C₁₈H₂₂D₆N₄O₈

Color and Shape: Neat

Molecular weight: 434.47

Ref: TR-H954037

Pyridinoline

CAS: 63800-01-1

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Formula: C₁₈H₂₈N₄O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 428.44 g/mol

Ref: 3D-FP182741