CAS 63804-15-9

Sulindac sodium

Description:

Sulindac sodium is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is a prodrug, meaning it is metabolized in the body to its active form, which inhibits cyclooxygenase (COX) enzymes, leading to decreased production of prostaglandins involved in inflammation and pain. The substance is characterized by its ability to alleviate symptoms associated with conditions such as arthritis and acute pain. Sulindac sodium is typically administered orally and is known for its relatively low gastrointestinal toxicity compared to other NSAIDs. Its chemical structure includes a sulfinyl group, which contributes to its pharmacological activity. The drug is also noted for its potential to exhibit antitumor effects, making it a subject of research in cancer therapy. As with any medication, it is important to consider potential side effects, including gastrointestinal issues, cardiovascular risks, and renal effects, necessitating careful monitoring during treatment.

Formula: C₂₀H₁₇FO₃S·Na

InChI: InChI=1/C20H17FO3S.Na/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23;/h3-10H,11H2,1-2H3,(H,22,23);/b17-9-;

InChI key: InChIKey=YWNNRQKUANBLPZ-WPTDRQDKNA-N

SMILES: C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3.[Na]

Synonyms:

• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, sodium salt (1:1), (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, sodium salt, (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, sodium salt, (Z)-
• 1H-indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, sodium salt, (1E)-
• Sodium sulindac
• Sulindac sodium

Sulindac sodium

CAS: 63804-15-9

Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.

Formula: C₂₀H₁₆FNaO₃S

Color and Shape: Solid

Molecular weight: 378.39

Ref: TM-T61585