CAS 639-36-1

Akuammidine

Description:

Akuammidine, with the CAS number 639-36-1, is an indole alkaloid derived from the seeds of the plant Voacanga africana, which is known for its psychoactive properties. This compound exhibits a complex structure characterized by a bicyclic indole framework, which contributes to its biological activity. Akuammidine is recognized for its potential pharmacological effects, including analgesic and anti-inflammatory properties, and has been studied for its interactions with various neurotransmitter systems. It is often explored in the context of traditional medicine and has garnered interest for its potential therapeutic applications. The substance is typically found in a crystalline form and is soluble in organic solvents, but its solubility in water is limited. As with many alkaloids, caution is advised regarding its use, as it may exhibit side effects or toxicity at certain dosages. Overall, akuammidine represents a fascinating area of study within natural product chemistry and pharmacology, highlighting the importance of plant-derived compounds in drug discovery.

Formula: C₂₁H₂₄N₂O₃

InChI: InChI=1S/C21H24N2O3/c1-3-12-10-23-17-9-15(12)21(11-24,20(25)26-2)18(23)8-14-13-6-4-5-7-16(13)22-19(14)17/h3-7,15,17-18,22,24H,8-11H2,1-2H3/b12-3-/t15-,17-,18-,21-/m0/s1

InChI key: InChIKey=RCEFXZXHYFOPIE-GJZACXSBSA-N

SMILES: C(OC)(=O)[C@]1(CO)[C@]2([N@@]3[C@@](C[C@]1(/C(=C\C)/C3)[H])(C4=C(C2)C=5C(N4)=CC=CC5)[H])[H]

Synonyms:

• (+)-Akuammidine
• Rhazine
• Sarpagan-16-carboxylic acid, 17-hydroxy-, methyl ester
• Rhazin
• Akuammidine

Akuammidine

CAS: 639-36-1

Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki

Formula: C₂₁H₂₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 352.43

Ref: TM-TN3367

Akuammidine

CAS: 639-36-1

Formula: C₂₁H₂₄N₂O₃

Purity: 95%~99%

Molecular weight: 352.434

Ref: BP-SBP03110

Akuammidine

CAS: 639-36-1

Akuammidine is an indole alkaloid, which is a naturally occurring compound found in the seeds of the plant *Picralima nitida*, commonly known as Akuamma. This plant source is native to regions in West Africa and has been traditionally used in local medicine. Akuammidine is known for interacting with multiple receptor systems, primarily engaging with opioid receptors, exhibiting affinity for both mu and kappa subtypes. This mechanism is similar, but not identical, to that of other alkaloids such as morphine. Due to this engagement with the opioid receptors, Akuammidine may contribute to analgesic effects.

Formula: C₂₁H₂₄N₂O₃

Purity: Min. 95%

Molecular weight: 243 g/mol

Ref: 3D-FA177888