CAS 639-81-6

Ergotaminine

Description:

Ergotaminine is a chemical compound derived from ergot alkaloids, primarily known for its use in the treatment of migraine headaches. It is classified as a semi-synthetic derivative of ergotamine, which is obtained from the fungus Claviceps purpurea. The compound exhibits properties that allow it to act as a vasoconstrictor, influencing blood flow and alleviating migraine symptoms. Ergotaminine has a complex structure characterized by multiple rings and functional groups, contributing to its pharmacological activity. It is typically administered in the form of tablets or injections, and its effects can include nausea and other side effects due to its potent action on vascular smooth muscle. The compound's mechanism of action involves agonism at serotonin receptors, particularly the 5-HT1B and 5-HT1D subtypes, which play a crucial role in regulating vascular tone. Due to its potential for toxicity and side effects, its use is generally limited to specific cases under medical supervision. As with all medications, careful consideration of contraindications and interactions is essential when prescribing ergotaminine.

Formula: C₃₃H₃₅N₅O₅

InChI: InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25+,26-,27-,32+,33-/m0/s1

InChI key: InChIKey=XCGSFFUVFURLIX-BRMNWJGKSA-N

SMILES: O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@H]5C=C6C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)(C)O2

Synonyms:

• (5′α,8α)-12′-Hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione
• 12'-Hydroxy-2'-methyl-5'a-(phenylmethyl)-8a-ergotaman-3',6',18-trione
• 639-81-6
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• Ergotaman-3′,6′,18-trione, 12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,8α)-
• Ergotaminine
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• Isoergotamine
• (5'alpha,8alpha)-5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman

Ergotaminine

Controlled Product

CAS: 639-81-6

Formula: C₃₃H₃₅N₅O₅

Color and Shape: Neat

Molecular weight: 581.66

Ref: 04-C13201610

Ergotamine EP Impurity B

CAS: 639-81-6

Formula: C₃₃H₃₅N₅O₅

Molecular weight: 581.67

Ref: ST-EA-CP-E74002

Ergotaminine

Controlled Product

CAS: 639-81-6

Ergotaminine is a drug used to treat migraine attacks. It belongs to the pharmacological agents and has a basic structure that is similar to ergotamine. Ergotamine is an alkaloid extracted from the fungus Claviceps purpurea, which is used as a drug for the treatment of migraine headaches. Ergotamine also has other pharmacological effects such as vasoconstriction and uterine contraction. Ergotamine can cause side effects such as nausea, vomiting, and diarrhea. One of its main disadvantages is that it can lead to drug interactions with other drugs because it interacts with cytochrome P450 enzymes in the liver by inhibiting them. Ergotamine also has analytical methods such as gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, and fluorescence detection. Ergotamine can be used for treating infectious diseases such as carcinoid syndrome or angiogenic process caused by nonsteroidal anti-inflammatory drugs (NSAIDs

Formula: C₃₃H₃₅N₅O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 581.7 g/mol

Ref: 3D-XE180555

Ergotaminine

CAS: 639-81-6

Alkaloids of rye ergot and their derivatives; salts thereof, nesoi

Formula: C₃₃H₃₅N₅O₅

Color and Shape: White Off-White Light Grey Crystalline Powder

Molecular weight: 581.26382

Ref: 45-1241550