CAS 639089-54-6

Tozasertib

Description:

Tozasertib, with the CAS number 639089-54-6, is a small molecule inhibitor primarily targeting the protein kinase activity of the Aurora kinases, which are crucial for cell division and mitotic processes. This compound is characterized by its role in cancer therapy, particularly in the treatment of various solid tumors and hematological malignancies. Tozasertib exhibits a specific mechanism of action by disrupting the normal function of Aurora kinases, leading to cell cycle arrest and apoptosis in cancer cells. Its chemical structure includes a core that allows for selective binding to the ATP-binding site of the target kinases. In preclinical and clinical studies, Tozasertib has shown promise in inhibiting tumor growth and enhancing the efficacy of other anticancer agents. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile. As research continues, Tozasertib may contribute to the development of targeted cancer therapies, offering hope for improved treatment outcomes.

Formula: C₂₃H₂₈N₈OS

InChI: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChI key: InChIKey=GCIKSSRWRFVXBI-UHFFFAOYSA-N

SMILES: S(C=1N=C(C=C(NC2=NNC(C)=C2)N1)N3CCN(C)CC3)C4=CC=C(NC(=O)C5CC5)C=C4

Synonyms:

• Cyclopropanecarboxylic acid N-[4-[[4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide
• Mk 0457
• N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
• Tozasertib
• cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]-2-pyrimidinyl]thio]phenyl]-
• cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-
• VX 680

N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

CAS: 639089-54-6

Formula: C₂₃H₂₈N₈OS

Purity: %

Color and Shape: Solid

Molecular weight: 464.5864

Ref: IN-DA00373W

Tozasertib

CAS: 639089-54-6

Tozasertib

Purity: ≥98%

Molecular weight: 464.59g/mol

Ref: 54-BUP16179

Tozasertib

CAS: 639089-54-6

Tozasertib

Purity: 98%

Molecular weight: 464.6g/mol

Ref: 54-OR1024411

Tozasertib

CAS: 639089-54-6

Formula: C₂₃H₂₈N₈OS

Color and Shape: Pale Brown Solid

Molecular weight: 464.59

Ref: 4Z-K-031034

Tozasertib

CAS: 639089-54-6

Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).

Formula: C₂₃H₂₈N₈OS

Purity: 99.99%

Color and Shape: Solid

Molecular weight: 464.59

Ref: TM-T2509

Tozasertib

CAS: 639089-54-6

Ref: 7W-GW0305

Tozasertib

Controlled Product

CAS: 639089-54-6

Applications A multikinase inhibitor once used for cancer treatment.
References Ulisse, S., et al.: J. Endocrinol., 204, 135 (2010), McDermott, U., et al.: Cancer Res., 70, 1625 (2010), Donato, N., et al.: Biochem., Pharmacol., 79, 688 (2010),

Formula: C₂₃H₂₈N₈OS

Color and Shape: Neat

Molecular weight: 464.59

Ref: TR-T700000

VX 680

CAS: 639089-54-6

Aurora kinase inhibitor; antineoplastic

Formula: C₂₃H₂₈N₈OS

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 464.59 g/mol

Ref: 3D-FM28353