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CAS 63950-06-1

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Esorubicin hydrochloride

Description:
Esorubicin hydrochloride is an anthracycline antibiotic and a derivative of doxorubicin, primarily used in cancer therapy. It exhibits potent antitumor activity by intercalating into DNA, thereby inhibiting DNA and RNA synthesis, which ultimately leads to cell death. The compound is characterized by its ability to generate free radicals, contributing to its cytotoxic effects. Esorubicin hydrochloride is typically administered intravenously and is known for its effectiveness against various malignancies, including breast cancer and other solid tumors. Its chemical structure includes a tetracyclic ring system, which is common among anthracyclines, and it possesses a hydrochloride salt form that enhances its solubility in aqueous solutions. While it is effective in cancer treatment, esorubicin hydrochloride can also exhibit side effects, including cardiotoxicity, which necessitates careful monitoring during therapy. Overall, its unique properties make it a valuable agent in oncological pharmacotherapy, although its use must be balanced with potential adverse effects.
Formula:C27H29NO10
InChI:InChI=1/C27H29NO10/c1-11-6-12(28)7-18(37-11)38-16-9-27(35,17(30)10-29)8-14-20(16)26(34)22-21(24(14)32)23(31)13-4-3-5-15(36-2)19(13)25(22)33/h3-5,11-12,16,18,29,32,34-35H,6-10,28H2,1-2H3
InChI key:InChIKey=RCFNNLSZHVHCEK-YGCMNLPTSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)C[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Synonyms:
  • (2S-(2alpha(8R*,10R*),4beta,6beta))-10-((4-Aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
  • (8S,10S)-10-(((2S,4R,6S)-4-Aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
  • 10-[(4-amino-6-methyltetrahydro-2H-pyran-2-yl)oxy]-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
  • 4'-Deoxydoxorubicin hydrochloride
  • 5,12-Naphthacenedione, 10-((4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (2S-(2alpha(8R*,10R*),4beta,6beta))-
  • 5,12-Naphthacenedione, 10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, [2S-[2α(8R*,10R*),4β,6β]]-
  • 5,12-Naphthacenedione, 10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
  • 5,12-Naphthacenedione, 10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
  • 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-((tetrahydro-4-amino-6-methyl-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-, hydrochloride, (2S-(2-alpha(8R*,10R),4-beta,6-beta))-
  • Escorubicin hydrochloride
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