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CAS 6398-98-7

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Amodiaquine dihydrochloride dihydrate

Description:
Amodiaquine dihydrochloride dihydrate is a chemical compound primarily used as an antimalarial agent. It belongs to the class of 4-aminoquinoline derivatives and is structurally related to chloroquine. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its use in pharmaceutical formulations. Its molecular formula reflects the presence of two hydrochloride ions and two water molecules, indicating its dihydrochloride dihydrate form. Amodiaquine acts by interfering with the heme detoxification process in the malaria parasite, ultimately leading to its death. While effective against certain strains of Plasmodium, its use has been limited due to concerns over potential side effects, including hepatotoxicity and the risk of developing resistance. As with many antimalarial drugs, careful consideration of dosage and monitoring for adverse reactions is essential in clinical settings. Additionally, it is important to note that the compound should be handled with care, following appropriate safety guidelines due to its pharmacological properties.
Formula:C20H22ClN3O·2ClH·2H2O
InChI:InChI=1S/C20H22ClN3O.2ClH.2H2O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H;2*1H2
InChI key:InChIKey=YVNAYSHNIILOJS-UHFFFAOYSA-N
SMILES:N(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN(CC)CC)=C(O)C=C3.Cl.O
Synonyms:
  • 4-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]Phenol
  • 4-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]Phenol Dihydrochloride
  • 4-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]Phenol Dihydrochloride Dihydrate
  • 5-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]Phenol Dihydrochloride
  • Amodiaquin dihydrochloride dihydrate
  • Amodiaquine dihydrochloride dihydrate
  • AmodiaquineHydrochloride
  • Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, dihydrochloride, dihydrate
  • Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride, hydrate (1:2:2)
  • o-Cresol, 4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-, dihydrochloride, dihydrate
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