CAS 64-72-2

Chlortetracycline hydrochloride

Description:

Chlortetracycline hydrochloride is a broad-spectrum antibiotic belonging to the tetracycline class, primarily used in veterinary medicine and some human applications. It is characterized by its yellow crystalline appearance and is soluble in water, which facilitates its use in various formulations. The compound exhibits antibacterial properties by inhibiting protein synthesis in bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms. Chlortetracycline hydrochloride is often utilized in the treatment of infections, as well as in agricultural settings to promote growth in livestock. Its mechanism of action involves binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA, thereby disrupting the translation process. While generally well-tolerated, it can cause side effects such as gastrointestinal disturbances and photosensitivity. Additionally, the use of tetracyclines has raised concerns regarding antibiotic resistance, necessitating careful consideration of its application in both human and veterinary medicine.

Formula: C₂₂H₂₃ClN₂O₈·ClH

InChI: InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7-,8-,15-,21-,22-;/m0./s1

InChI key: InChIKey=CBHYYLPALVVVEY-MRFRVZCGSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C([C@@]3(C)O)=C(Cl)C=CC4O)[H])[H].Cl

Synonyms:

• (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• (2Z,4S,4aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
• 7-Chlorotetracycline hydrochloride
• 7-Chlorotetracycline monohydrochloride
• Aureociclina
• Aureocycline
• Aureomycin monohydrochloride
• Aureovit 12C80
• Aurofac 100
• Biomycin hydrochloride
• Chlortetracycline hydrochloride
• Chlortetracyclinium chloride
• Fermycin Soluble
• Isphamycin

Chlortetracycline Hydrochloride

Controlled Product

CAS: 64-72-2

Applications Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.Chlortetracycline contains an undetermined amount of epi-chlortetracycline.
References Skaletzki, B., et al.: Pharmazie, 29, 424 (1974), Martinez, M., et al.: Biochemistry, 40, 11965 (2001), Davidson, P., et al.: Food Technol., 55, 69 (2002), de la Fuente, R., et al.: Br. J. Pharmacol., 149, 551 (2006),

Formula: C₂₂H₂₃ClN₂O₈·ClH

Color and Shape: Neat

Molecular weight: 515.34

Ref: TR-C426500

Chlortetracycline-13C-d3 Hydrochloride (Technical Grade, may contain up to 1.5% d0)

Controlled Product

CAS: 64-72-2

Formula: C₂₁CH₂₀D₃ClN₂O₈·HCl

Color and Shape: Neat

Molecular weight: 534.386

Ref: TR-C426510

Chlorotetracycline monohydrochloride, Antibiotic for Culture Media Use Only

CAS: 64-72-2

Chlorotetracycline monohydrochloride is an antibiotic compound specifically designed for culture media use. It is derived from a naturally occurring tetracycline produced by the bacterium *Streptomyces aureofaciens*. As a broad-spectrum antibiotic, chlorotetracycline functions by inhibiting protein synthesis in susceptible bacteria. It binds to the 30S subunit of the bacterial ribosome, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor site, which effectively halts translational elongation.

Formula: C₂₂H₂₄Cl₂N₂O₈

Purity: (Chlortetracycline Hcl) Min. 89.5%

Color and Shape: Yellow Powder

Molecular weight: 515.34 g/mol

Ref: 3D-AC162429

Chlortetracycline hydrochloride

CAS: 64-72-2

Chlortetracycline hydrochloride is a broad-spectrum antibiotic, which is derived from the bacterium *Streptomyces aureofaciens*. It operates by inhibiting protein synthesis in susceptible bacteria through binding to the 30S ribosomal subunit. This mechanism effectively blocks the attachment of aminoacyl-tRNA to the mRNA-ribosome complex, thereby preventing the addition of new amino acids to the nascent peptide chain.

Formula: C₂₂H₂₄Cl₂N₂O₈

Purity: Min. 89.5%

Color and Shape: Yellow Powder

Molecular weight: 515.34 g/mol

Ref: 3D-AC20413

Chlorotetracycline monohydrochloride, Antibiotic for Culture Media Use Only

CAS: 64-72-2

Chlorotetracycline monohydrochloride is an antibiotic designed for culture media use. It is derived from the bacterium *Streptomyces aureofaciens*, and functions primarily by inhibiting bacterial protein synthesis. This action prevents the attachment of aminoacyl-tRNA to the ribosomal acceptor site, effectively halting the growth of bacteria by disrupting protein production, which is essential for their survival and replication.

Formula: C₂₂H₂₄Cl₂N₂O₈

Purity: (Chlortetracycline Hcl) Min. 89.5%

Molecular weight: 515.34 g/mol

Ref: 3D-C-5490

Lymecycline EP Impurity G

CAS: 64-72-2

Formula: C₂₂H₂₃ClN₂O₈HCl

Molecular weight: 478.88 : 36.46

Ref: ST-EA-CP-L64007