CAS 64-86-8
:Colchicine
Description:
Colchicine is a potent alkaloid derived from the plant Colchicum autumnale, commonly known as the autumn crocus. It is characterized by its ability to inhibit microtubule polymerization, which disrupts cellular mitosis and is primarily used in the treatment of gout and familial Mediterranean fever. Colchicine appears as a white to off-white crystalline powder and is soluble in water, alcohol, and chloroform, but poorly soluble in ether. Its chemical formula is C22H25NO6, and it has a molecular weight of approximately 399.44 g/mol. Colchicine exhibits anti-inflammatory properties and is also studied for its potential effects in various diseases, including cardiovascular conditions and certain cancers. However, it has a narrow therapeutic window, meaning that the difference between an effective dose and a toxic dose is small, necessitating careful monitoring during use. Adverse effects can include gastrointestinal disturbances, bone marrow suppression, and peripheral neuropathy, making it essential for patients to be under medical supervision when using this compound.
Formula:C22H25NO6
InChI:InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChI key:InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N
SMILES:O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3
Synonyms:- (-)-Colchicine
- (S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
- (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
- Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
- Benzo[a]heptalene, acetamide deriv.
- Colchicin
- Colchicina
- Colchicine Fu
- Colchineos
- Colchisol
- Colcin
- Colcrys
- Colsaloid
- Condylon
- Mitigare
- N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
- Nsc 757
- See more synonyms
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Colchicine (contains 5% Ethyl Acetate at maximum)
CAS:Formula:C22H25NO6Purity:>97.0%(HPLC)Color and Shape:White to Orange to Green powder to crystalMolecular weight:399.44Colchicine, 95% (dry wt.)
CAS:Colchicine is used as an anti-inflammatory agent for long-term treatment of behcet's Disease. It is used for constipation-predominant irritable bowel syndrome in women, and for treatment of severe or persistent aphthous stomatitis (canker sores).This Thermo Scientific Chemicals brand product was oriFormula:C22H25NO6Purity:95%Color and Shape:White to pale cream to pale yellow, PowderMolecular weight:399.44Colchicine
CAS:ColchicineFormula:C22H25NO6Purity:94.6%Color and Shape:BeigeMolecular weight:399.16819Colchicine
CAS:Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoiFormula:C22H25NO6Color and Shape:Light Yellow Light Green Crystalline Powder Amorphous PowderMolecular weight:399.44Colchicine
CAS:Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding toFormula:C22H25NO6Purity:98% - 99.96%Color and Shape:Pale Yellow Scales Or Powder; Pale Yellow Needles When Crystallized From Ethyl Acetate To Light Used To Treat Gouty Arthritis Pseudogout Sarcoidal Arthritis And Calcific Tendinitis (EpaMolecular weight:399.44Colchicine, USP grade
CAS:Formula:C22H25NO6Purity:≤ 5.0%Color and Shape:White to yellow powderMolecular weight:399.44Colchicine
CAS:Formula:C22H25NO6Purity:≥ 95.0% (dried, solvent-free basis)Color and Shape:White to yellow powderMolecular weight:399.44Colchicine
CAS:Natural alkaloidFormula:C22H25NO6Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:399.44(S)-Colchicine >95%
CAS:Controlled ProductApplications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),Formula:C22H25NO6Purity:>95%Color and Shape:Light YellowMolecular weight:399.44Colchicine
CAS:Used as gout medication; anti-inflammatoryFormula:C22H25NO6Purity:Min. 94 Area-%Color and Shape:White PowderMolecular weight:399.44 g/molColchicine, 98%
CAS:Microtubule disrupting agent, and induces apoptosis in human lymphoma cells
Formula:C22H25NO6Purity:98%Color and Shape:Powder, White to pale yellowMolecular weight:399.44
