CAS 64013-70-3

Kanamycin disulfate

Description:

Kanamycin disulfate is an aminoglycoside antibiotic derived from the bacterium Micromonospora purpurea. It is primarily used to treat infections caused by certain bacteria, particularly those resistant to other antibiotics. The substance is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, which disrupts the translation process. Kanamycin disulfate is typically administered via injection and is effective against a range of Gram-negative and some Gram-positive bacteria. It is known for its potential nephrotoxicity and ototoxicity, necessitating careful monitoring of kidney function and hearing during treatment. The compound is soluble in water, which facilitates its use in clinical settings. Additionally, it is important to note that resistance to kanamycin can develop, often due to enzymatic modification by bacteria. As with all antibiotics, appropriate susceptibility testing is recommended to ensure its effectiveness against specific pathogens.

Formula: C₁₈H₃₆N₄O₁₁·2H₂O₄S

InChI: InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key: InChIKey=OOYGSFOGFJDDHP-KMCOLRRFSA-N

SMILES: S(=O)(=O)(O)O.O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:2)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:2) (salt)
• Canamycin A disulfate
• Kanamycin A disulfate
• Kanamycin disulfate
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:2) (salt)
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:2)

Kanamycin disulfate, 700&mu;g/mg

CAS: 64013-70-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₈H₄₀N₄O₁₉S₂

Color and Shape: White to off-white, Powder

Molecular weight: 680.65

Ref: 02-J66856

Kanamycin disulfate salt

CAS: 64013-70-3

Formula: C₁₈H₄₀N₄O₁₉S₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 680.6556

Ref: IN-DA003R67

Kanamycin disulfate salt

CAS: 64013-70-3

Formula: C₁₈H₃₆N₄O₁₁·2H₂SO₄·xH₂O

Purity: ≥ 670IU/mg (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 680.65 (anhydrous)

Ref: 7W-GA8523

Kanamycin Acid Sulfate

Controlled Product

CAS: 64013-70-3

Applications Kanamycin acid sulfate is the sulfate salt form of Kanamycin A, an antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.
References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),

Formula: C₁₈H₃₆N₄O₁₁·2(H₂SO₄)

Color and Shape: White To Off-White

Molecular weight: 680.6556

Ref: TR-K571205

Kanamycin disulfate

CAS: 64013-70-3

Binds to 70S ribosomal subunit; inhibits translocation and induces miscoding

Formula: C₁₈H₃₆N₄O₁₁·2H₂O₄S

Purity: Min. 67%

Color and Shape: Powder

Molecular weight: 680.66 g/mol

Ref: 3D-AK65050

Kanamycin Acid Sulphate (KS) for tissue culture, 670U/mg

CAS: 64013-70-3

Formula: C₁₈H₄₀N₄O₁₉S₂

Color and Shape: White to off white, Powder, Clear, Colourless to pale yellow

Molecular weight: 680.65

Ref: SR-89346

Kanamycin Acid Sulphate (KS) extrapure, 670U/mg

CAS: 64013-70-3

Formula: C₁₈H₄₀N₄O₁₉S₂

Color and Shape: White to off white, Powder, Clear, Colourless to pale yellow

Molecular weight: 680.65

Ref: SR-70878