CAS 64053-00-5

Zuclopenthixol decanoate

Description:

Zuclopenthixol decanoate is an antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It is a long-acting injectable formulation of zuclopenthixol, which is a thioxanthene derivative. This substance acts primarily as a dopamine antagonist, influencing neurotransmitter activity in the brain, particularly dopamine receptors, which helps to alleviate symptoms of psychosis. Zuclopenthixol decanoate is characterized by its lipid solubility, allowing for prolonged release and sustained therapeutic effects when administered intramuscularly. The decanoate esterification enhances its duration of action compared to the non-esterified form. Common side effects may include sedation, extrapyramidal symptoms, and metabolic changes. It is important to monitor patients for these effects and adjust dosages accordingly. As with any antipsychotic, careful consideration of the risk-benefit profile is essential in clinical practice. The substance is typically administered in a clinical setting, and its use is guided by established treatment protocols for managing severe psychiatric conditions.

Formula: C₃₂H₄₃ClN₂O₂S

InChI: InChI=1S/C32H43ClN2O2S/c1-2-3-4-5-6-7-8-15-32(36)37-24-23-35-21-19-34(20-22-35)18-11-13-27-28-12-9-10-14-30(28)38-31-17-16-26(33)25-29(27)31/h9-10,12-14,16-17,25H,2-8,11,15,18-24H2,1H3/b27-13-

InChI key: InChIKey=QRUAPADZILXULG-WKIKZPBSSA-N

SMILES: C(\CCN1CCN(CCOC(CCCCCCCCC)=O)CC1)=C/2\C=3C(SC=4C2=CC=CC4)=CC=C(Cl)C3

Synonyms:

• 9H-Thioxanthene, decanoic acid deriv.
• Decanoic acid, 2-(4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-1-piperazinyl)ethyl ester, (Z)-
• Decanoic acid, 2-[4-[(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazinyl]ethyl ester
• Zuclopenthixol decanoate
• Zuclopenthixol HCl
• 64053-00-5 ZUCLOPENTHIXOL DECANOATE
• 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethyl decanoate
• (Z)-2-(4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethyl decanoate
• 2-[4-[3-[(9Z)-2-Chloro-9H-thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethyl decanoate.
• Zuclopenthixol decant impurity

Zuclopenthixol decanoate dihydrochloride

CAS: 64053-00-5

Zuclopenthixol decanoate dihydrochloride

Formula: C₃₂H₄₃ClN₂O₂SHCl

Purity: 99.7%

Color and Shape: White

Molecular weight: 590.25006

Ref: 47-596

Zuclopenthixol Decanoate EP Impurity A DiHCl (Z-Isomer)

CAS: 64053-00-5

Formula: C₃₂H₄₃ClN₂O₂S·2HCl

Color and Shape: Pale Yellow Solid

Molecular weight: 555.23 2*36.46

Ref: 4Z-Z-102

Zuclopenthixol Decanoate-d19

Controlled Product

CAS: 64053-00-5

Formula: C₃₂H₂₄D₁₉ClN₂O₂S

Color and Shape: Neat

Molecular weight: 574.33

Ref: TR-Z701493

Zuclopenthixol-D4 Decanoate

Controlled Product

CAS: 64053-00-5

Formula: C₃₂H₃₉D₄ClN₂O₂S

Color and Shape: Neat

Molecular weight: 559.24

Ref: TR-Z701492

Zuclopenthixol Decanoate

Controlled Product

CAS: 64053-00-5

Applications Zuclopenthixol Decanoate is used in the maintenance treatment of chronic schizophrenic patients. it is one of the three distinct formulations of Zuclopenthixol namely, zuclopenthixol dihydrochloride, zuclopenthixol acetate or Acuphase and zuclopenthixol decanoate.
References Wistedt B, et al; Acta Psychiatr Scand. 1991 Jul;84(1):14-21Izmeth MG, et al; Pharmatherapeutica. 1988;5(4):217-27.

Formula: C₃₂H₄₃ClN₂O₂S

Color and Shape: Neat

Molecular weight: 555.21

Ref: TR-Z701490

Zuclopenthixol decanoate

Controlled Product

CAS: 64053-00-5

Zuclopenthixol decanoate is an antipsychotic drug that is used to treat chronic schizophrenia. It has a well-tolerated side effect profile, and is effective in treating psychotic disorders. Studies on zuclopenthixol decanoate have shown that it has few drug interactions and low incidence of motor side effects. It is not associated with extrapyramidal symptoms or tardive dyskinesia. Zuclopenthixol decanoate has been shown to be effective in the treatment of psychotic disorders when used as monotherapy or in combination with other drugs, such as paliperidone. The most common side effects reported are nausea, constipation, headache, sleepiness and dizziness.

Formula: C₃₂H₄₃ClN₂O₂S

Purity: Min. 95%

Molecular weight: 555.2 g/mol

Ref: 3D-PCA05300

Zuclopenthixol decanoate

CAS: 64053-00-5

Zuclopenthixol decanoate is an anti-schizophrenia drug.

Formula: C₃₂H₄₃ClN₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 555.21

Ref: TM-T4117L