CAS 64118-81-6

Diclofenac glucuronide

Description:

Diclofenac glucuronide is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, which is commonly used to relieve pain and inflammation. This compound is formed through the conjugation of diclofenac with glucuronic acid, a process that enhances its solubility and facilitates excretion from the body. Diclofenac glucuronide is characterized by its relatively high polarity compared to its parent compound, which affects its pharmacokinetics and bioavailability. It is typically found in biological fluids, such as urine, following the administration of diclofenac. The compound exhibits anti-inflammatory properties, although it is less potent than diclofenac itself. Its presence in biological samples is often used as a biomarker for diclofenac exposure and can be relevant in pharmacokinetic studies. Additionally, understanding the characteristics of diclofenac glucuronide is important for assessing potential drug interactions and the overall metabolic pathway of diclofenac in the human body.

Formula: C₂₀H₁₉Cl₂NO₈

InChI: InChI=1S/C20H19Cl2NO8/c21-10-5-3-6-11(22)14(10)23-12-7-2-1-4-9(12)8-13(24)30-20-17(27)15(25)16(26)18(31-20)19(28)29/h1-7,15-18,20,23,25-27H,8H2,(H,28,29)/t15-,16-,17+,18-,20+/m0/s1

InChI key: InChIKey=JXIKYYSIYCILNG-HBWRTXEVSA-N

SMILES: N(C1=C(CC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)C=CC=C1)C3=C(Cl)C=CC=C3Cl

Synonyms:

• Diclofenac glucuronide
• Diclofenac-β-<span class="text-smallcaps">D</span>-glucuronide
• Diclofenacglucuronide
• β-<span class="text-smallcaps">D</span>-Glucopyranuronic acid, 1-[2-[(2,6-dichlorophenyl)amino]benzeneacetate]
• β-D-Glucopyranuronic acid, 1-[2-[(2,6-dichlorophenyl)amino]benzeneacetate]
• Diclofenac-β-D-glucuronide

Diclofenac-acyl-β-D-glucuronide

CAS: 64118-81-6

Formula: C₂₀H₁₉Cl₂NO₈

Color and Shape: White To Off-White Solid

Molecular weight: 472.28

Ref: 4Z-D-064

Diclofenac Acyl Glucuronide

CAS: 64118-81-6

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.

Formula: C₂₀H₁₉Cl₂NO₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 472.27

Ref: TM-T27167

Diclofenac acyl-D-glucuronide

CAS: 64118-81-6

Ref: 7W-GC8579

Diclofenac-d4 Acyl Glucuronide

CAS: 64118-81-6

Formula: C₂₀H₁₅Cl₂NO₈D₄

Color and Shape: Pale Purple Solid

Molecular weight: 476.31

Ref: 4Z-D-0630

Diclofenac-acyl-β-D-glucuronide

CAS: 64118-81-6

Diclofenac-acyl-β-D-glucuronide

Purity: 95%

Color and Shape: White To Yellow Solid

Molecular weight: 472.27g/mol

Ref: 54-BICL4062

Diclofenac Acyl-β-D-glucuronide

Controlled Product

CAS: 64118-81-6

Applications A metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.
References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004)

Formula: C₂₀H₁₉Cl₂NO₈

Color and Shape: Neat

Molecular weight: 472.27

Ref: TR-D436475

Diclofenac acyl-D-glucuronide

CAS: 64118-81-6

Diclofenac acyl-D-glucuronide is a nonsteroidal anti-inflammatory drug that inhibits the enzyme activity of aminotransferase. This leads to a decrease in the production of prostaglandins, which are responsible for the inflammatory response. Diclofenac acyl-D-glucuronide has been shown to have antiulcer effects in vitro and in vivo. It also decreases the uptake of diclofenac by human tubule cells, which may be due to its reactive nature. The clinical relevance of this drug is still under investigation, but it is believed that diclofenac acyl-D-glucuronide could play a role in wastewater treatment because it can be easily extracted from water samples with analytical chemistry techniques.

Formula: C₂₀H₁₉Cl₂NO₈

Purity: Min. 95 Area-%

Color and Shape: Off-White Yellow Powder

Molecular weight: 472.27 g/mol

Ref: 3D-MD07328

Diclofenac Acyl-β-D-glucuronide

CAS: 64118-81-6

Formula: C₂₀H₁₉Cl₂NO₈

Molecular weight: 472.27

Ref: ST-EA-CP-D20088