CAS 64118-84-9

4′-Hydroxydiclofenac

Description:

4′-Hydroxydiclofenac is a derivative of diclofenac, a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain and inflammation. This compound features a hydroxyl group at the para position of the phenyl ring, which alters its pharmacological properties compared to its parent compound. It is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its organic nature. The presence of the hydroxyl group enhances its solubility in water compared to diclofenac, potentially influencing its bioavailability and therapeutic efficacy. 4′-Hydroxydiclofenac exhibits anti-inflammatory and analgesic activities, making it relevant in pharmacological research. Its mechanism of action is primarily through the inhibition of cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain signaling. Additionally, the compound's safety profile and potential side effects are important considerations in its therapeutic application. Overall, 4′-Hydroxydiclofenac represents a significant area of study in the development of more effective and safer anti-inflammatory medications.

Formula: C₁₄H₁₁Cl₂NO₃

InChI: InChI=1/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)

InChI key: InChIKey=KGVXVPRLBMWZLG-UHFFFAOYSA-N

SMILES: N(C1=C(Cl)C=C(O)C=C1Cl)C2=C(CC(O)=O)C=CC=C2

Synonyms:

• 2-((2,6-Dichloro-4-hydroxyphenyl)amino)benzeneacetic acid
• Benzeneacetic acid, 2-[(2,6-dichloro-4-hydroxyphenyl)amino]-
• {2-[(2,6-Dichloro-4-Hydroxyphenyl)Amino]Phenyl}Acetic Acid
• 4′-Hydroxydiclofenac
• (o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid
• 4-OHD
• 4'-HYDROXYDICLOFENAC STANDARD
• 4-HYDROXY DICLOFENAC
• 4′-Hydroxydiclofenac solution
• 2-(2,6-Dichloro-4-hydroxyanilino)benzeneacetic acid
• Hydroxydiclofenac
• (o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci
• 4'-OHD
• DICLOFENAC, 4'-HYDROXY-
• 2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID

4'-Hydroxydiclofenac

CAS: 64118-84-9

A Cytochrome P450 2C9 (CYP2C9) metabolite of diclofenac

Formula: C₁₄H₁₁Cl₂NO₃

Color and Shape: Powder

Molecular weight: 312.15

Ref: 02-J64095

2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID

CAS: 64118-84-9

Formula: C₁₄H₁₁Cl₂NO₃

Purity: %

Color and Shape: Solid

Molecular weight: 312.1480

Ref: IN-DA00E8TT

4'-Hydroxy Diclofenac

CAS: 64118-84-9

Formula: C₁₄H₁₁Cl₂NO₃

Color and Shape: Off-White Solid

Molecular weight: 312.15

Ref: 4Z-D-062

Diclofenac-4-hydroxy

Controlled Product

CAS: 64118-84-9

Formula: C₁₄H₁₁Cl₂NO₃

Color and Shape: Neat

Molecular weight: 312.15

Ref: 04-C12537080

4'-Hydroxydiclofenac

CAS: 64118-84-9

Color and Shape: Neat

Ref: 86-MM0006.23

4''-Hydroxydiclofenac

CAS: 64118-84-9

Formula: C₁₄H₁₁Cl₂NO₃

Molecular weight: 312.15

Ref: 7W-GL1668

4’-Hydroxy Diclofenac

Controlled Product

CAS: 64118-84-9

Stability Light Sensitive
Applications A metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kretz-Rommel, A., et al.: Toxicol. Appl. Pharmacol., 120, 155 (1993), Petronilli, V., et al.: J. Biol. Chem., 269, 16638 (1994), Bort, R., et al.: J. Pharmacol. Exp. Ther., 288, 65 (1998), Poon, G., et al.: Drug Metab. Dispos., 29, 1608 (2001),

Formula: C₁₄H₁₁Cl₂NO₃

Color and Shape: White To Light Purple

Molecular weight: 312.15

Ref: TR-H825225

4'-Hydroxy diclofenac

CAS: 64118-84-9

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid group. The major route of elimination of diclofenac is through glucuronidation by UGT1A9 and UGT2B7. This process, which leads to the formation of a glucuronide conjugate with diclofenac, is often competitively inhibited by drugs that are substrates for these enzymes. In vivo models have shown that 5-hydroxy omeprazole inhibits the formation of the glucuronide conjugate and increases plasma levels of free diclofenac. A preparative high-performance liquid chromatography method has been developed for determining diclofenac in wastewater samples. Diclofenac is an antirheumatic drug used to treat osteoarthritis and rheumatoid arthritis. Chronic oral administration of diclofenac leads to increased concentrations in

Formula: C₁₄H₁₁Cl₂NO₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 312.15 g/mol

Ref: 3D-FH23980

4'-Hydroxy diclofenac

CAS: 64118-84-9

4'-Hydroxydiclofenac is a diclofenac metabolite.

Formula: C₁₄H₁₁Cl₂NO₃

Color and Shape: Light Violet Solid

Molecular weight: 312.15

Ref: TM-T19819

4-Hydroxy Diclofenac

CAS: 64118-84-9

Formula: C₁₄H₁₁Cl₂NO₃

Molecular weight: 312.15

Ref: ST-EA-CP-D20032