CAS 64145-26-2

Adenosine, 2'-deoxy-,5'-(dihydrogen phosphorothioate)

Description:

Adenosine, 2'-deoxy-,5'-(dihydrogen phosphorothioate), commonly referred to as a phosphorothioate derivative of deoxyadenosine, is a modified nucleoside that incorporates a sulfur atom in place of one of the oxygen atoms in the phosphate group. This modification enhances the stability of the molecule against enzymatic degradation, making it useful in various biochemical applications, particularly in the field of molecular biology and therapeutic development. The compound retains the core structure of adenosine, which consists of a purine base (adenine) linked to a sugar (deoxyribose), with the phosphorothioate group attached at the 5' position. This alteration can influence the compound's interaction with nucleic acids, potentially enhancing its affinity for specific targets. Additionally, phosphorothioate modifications are often employed in antisense oligonucleotides and siRNA to improve cellular uptake and resistance to nucleases. Overall, this compound exemplifies the strategic modifications made to nucleosides to enhance their functional properties in research and therapeutic contexts.

Formula: C₁₀H₁₄N₅O₅PS

Synonyms:

• 2'-Deoxyadenosine5'-O-thiophosphate

2'-Deoxyadenosine 5'-O-thiophosphate sodium salt

CAS: 64145-26-2

2'-Deoxyadenosine 5'-O-thiophosphate sodium salt is a synthetic nucleotide that has antiviral, anticancer and antitumor properties. It is a modified deoxyribonucleoside and it activates the synthesis of DNA by acting as an activator. This drug is not found in nature and it has shown to inhibit the growth of human breast cancer cells in cell culture.

Formula: C₁₀H₁₄N₅O₅PS

Purity: Min. 95%

Molecular weight: 347.29 g/mol

Ref: 3D-ND166620