CAS 64145-29-5

2'-deoxy-5'-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphorothioyl)cytidine

Description:

2'-Deoxy-5'-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphorothioyl)cytidine, with CAS number 64145-29-5, is a nucleoside analog characterized by its structural modifications that enhance its biological activity. This compound features a cytidine base, which is a pyrimidine nucleoside, linked to a deoxyribose sugar, indicating it is a derivative of DNA rather than RNA. The presence of a phosphorothioate group introduces a sulfur atom in place of one of the oxygen atoms in the phosphate backbone, which can improve the stability of the molecule against enzymatic degradation. Additionally, the hydroxy groups contribute to its solubility and potential interactions with biological targets. This compound is of interest in medicinal chemistry and molecular biology, particularly for its potential applications in antiviral and anticancer therapies, as it may interfere with nucleic acid synthesis or function. Its unique structural features make it a valuable tool for research in nucleic acid chemistry and therapeutic development.

Formula: C₉H₁₆N₃O₁₂P₃S

InChI: InChI=1/C9H16N3O12P3S/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(22-8)4-21-27(20,28)24-26(18,19)23-25(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,28)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+,27?/m0/s1

2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt - 10 mM aqueous solution

CAS: 64145-29-5

2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt is a nucleotide analog that inhibits the synthesis of DNA. It inhibits transcription and replication of HIV. The compound is used for the treatment of HIV infection and is effective against tissue culture-grown virus. 2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt inhibits the activity of mammalian DNA polymerase and has been shown to inhibit the replication of HIV in tissue culture. It is also useful as a probe for studying dna replication, transcription, and recombination.

Formula: C₉H₁₆N₃O₁₂P₃S·xNa

Purity: Min. 95%

Molecular weight: 483.22 g/mol

Ref: 3D-ND32069