5-Methyl-1-(β-L-ribofuranosyl)uracil, with the CAS number 642082-80-2, is a nucleoside analog that features a uracil base modified with a methyl group at the 5-position and a ribofuranosyl sugar moiety. This compound is characterized by its structural components, which include a pyrimidine ring and a ribose sugar, contributing to its potential biological activity. The methylation at the 5-position can influence the compound's stability, solubility, and interaction with nucleic acids and enzymes. It may exhibit properties similar to those of natural nucleosides, potentially participating in nucleic acid synthesis or serving as a substrate for various enzymatic reactions. The β-anomeric configuration of the ribofuranosyl group suggests that it is likely to adopt a specific conformation that could affect its binding affinity to nucleic acid targets. Research into such nucleoside analogs often focuses on their therapeutic potential, particularly in antiviral or anticancer applications, due to their ability to interfere with nucleic acid metabolism.

5-METHYL-1-(β-L-RIBOFURANOSYL)URACIL

642082-80-2: 5-Methyl-1-(β-L-ribofuranosyl)uracil, with the CAS number 642082-80-2, is a nucleoside analog that features a uracil base modified with a methyl group at the 5-position and a ribofuranosyl sugar moiety. This compound is characterized by its structural components, which include a pyrimidine ring and a ribose sugar, contributing to its potential biological activity. The methylation at the 5-position can influence the compound's stability, solubility, and interaction with nucleic acids and enzymes. It may exhibit properties similar to those of natural nucleosides, potentially participating in nucleic acid synthesis or serving as a substrate for various enzymatic reactions. The β-anomeric configuration of the ribofuranosyl group suggests that it is likely to adopt a specific conformation that could affect its binding affinity to nucleic acid targets. Research into such nucleoside analogs often focuses on their therapeutic potential, particularly in antiviral or anticancer applications, due to their ability to interfere with nucleic acid metabolism.

<p>L-5-methyluridine is a nucleoside that is used as a building block in the synthesis of oligonucleotides. It contains one ribose sugar and one deoxyribose sugar, linked to the base adenine by a phosphate group. L-5-methyluridine can be synthesized from 5-chloro-2'-deoxyadenosine, hypoxanthine, and ammonium chloride. The synthesis starts with condensation reactions between the two sugar molecules to form an intermediate called a nucleoside. This is followed by alkylation of the base and then oxidation of the sugar group to form anomeric esters. The last step involves hydrolysis of the acyloxy ester, which yields L-5-methyluridine after acidification.</p>

CAS 642082-80-2

5-METHYL-1-(β-L-RIBOFURANOSYL)URACIL

L-5-methyluridine

Ref: 3D-NM57493