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CAS 64211-45-6

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Oxiconazole

Description:
Oxiconazole is an antifungal agent belonging to the imidazole class of compounds, primarily used in the treatment of various fungal infections. Its chemical structure features a 1,2-dihydro-2-phenyl-1H-imidazole moiety, which contributes to its antifungal activity by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Oxiconazole is typically characterized by its white to off-white crystalline appearance and is soluble in organic solvents such as ethanol and methanol, but has limited solubility in water. The compound exhibits a broad spectrum of activity against dermatophytes, yeasts, and other fungi, making it effective for topical applications in dermatological formulations. Additionally, it has a relatively low toxicity profile, which enhances its suitability for use in various formulations. Oxiconazole is often found in creams, lotions, and powders, and is applied directly to the affected areas to combat fungal infections. Its efficacy, combined with a favorable safety profile, makes it a valuable option in antifungal therapy.
Formula:C18H13Cl4N3O
InChI:InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18+
InChI key:InChIKey=QRJJEGAJXVEBNE-HKOYGPOVSA-N
SMILES:C(\CN1C=CN=C1)(=N\OCC2=C(Cl)C=C(Cl)C=C2)/C3=C(Cl)C=C(Cl)C=C3
Synonyms:
  • (1E)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-(2,4-dichlorobenzyl)oxime
  • (1Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-(2,4-dichlorobenzyl)oxime
  • (1Z)-N-[(2,4-Dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine
  • 2',4'-Dichlor-O-(2,4-dichlorbenzyl)-2-(1-imidazolyl)-(Z)-acetophenonoxim
  • Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-[(2,4-dichlorophenyl)methyl]oxime, (Z)-
  • Oxiconazol
  • Oxiconazolum
  • ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-[(2,4-dichlorophenyl)methyl]oxime, (1Z)-
  • Oxiconazole
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