CAS 64228-79-1

Atracurium

Description:

Atracurium is a non-depolarizing neuromuscular blocking agent commonly used in anesthesia to facilitate intubation and provide muscle relaxation during surgical procedures. It acts by competitively inhibiting the action of acetylcholine at the neuromuscular junction, leading to muscle paralysis. Atracurium is characterized by its rapid onset and intermediate duration of action, making it suitable for various surgical settings. One of its notable features is its unique metabolism; it undergoes spontaneous degradation at physiological pH and temperature, as well as being metabolized by non-specific plasma esterases, which makes it particularly useful in patients with renal or hepatic impairment. The drug is typically administered intravenously and is often preferred in situations where rapid recovery of neuromuscular function is desired. Common side effects may include hypotension and allergic reactions, although these are relatively rare. Overall, atracurium is valued for its efficacy and safety profile in clinical practice.

Formula: C₅₃H₇₂N₂O₁₂

InChI: InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2

InChI key: InChIKey=YXSLJKQTIDHPOT-UHFFFAOYSA-N

SMILES: C(C1C=2C(=CC(OC)=C(OC)C2)CC[N+]1(CCC(OCCCCCOC(CC[N+]3(C)C(CC4=CC(OC)=C(OC)C=C4)C=5C(CC3)=CC(OC)=C(OC)C5)=O)=O)C)C6=CC(OC)=C(OC)C=C6

Synonyms:

• 2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]
• Atracurium
• Isoquinolinium, 2,2′-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-

Atracurium

CAS: 64228-79-1

Atracurium (BW-33A) is a competitive AChR antagonist and non-depolarizing muscle relaxant that may cause bronchoconstriction.

Formula: C₅₃H₇₂N₂O₁₂₂

Color and Shape: Solid

Molecular weight: 929.14

Ref: TM-T75283